Seated Control, Walking
Conditions
Brief summary
Walking is encouraged for people with type 2 diabetes but there is little evidence that performing a bout of walking can improve glucose control. Furthermore, it is unknown how participant characteristics (e.g., age, sex, medications) impact the acute glucose responses to walking in people with type 2 diabetes. The primary purpose of this study is to examine how a standardized bout of walking impacts glucose control assessed over 24 hours using continuous glucose monitoring. A secondary purpose is to determine whether responses are influenced by age, sex, and medication use.
Interventions
BEHAVIORALWalking
Walking on a treadmill at 3.5 METS for 50 minutes
BEHAVIORALSeated Control
Sitting for 50 minutes
Sponsors
University of Alberta
University of Calgary
McMaster University
Université de Sherbrooke
Centre Hospitalier de l'Université Laval
Children's Hospital Research Institute of Manitoba
Medtronic
University of British Columbia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with T2D for more than 6 months * 30-90 years of age * No contra-indications to exercise (PAR-Q+, Rose Angina questionnaire, limited ability to walk for 50 min). * No previous myocardial infarction, stroke or diagnosed coronary artery disease * No changes in diabetes medication in last 3 months * Not treated by insulin or corticosteroids * No significant change in body weight (\>5%) in last 3 months * Blood pressure \<160/100 mmHg; resting HR\<100 * Able to understand English or French and comply with study requirements (e.g., attend visits during the day) * Hemoglobin A1C \<9.0% * No prior history of hypoglycaemia during activity or sleep
Exclusion criteria
* Chest pain during physical activity. * Chest pain while resting (no physical activity) in the past month. * Loss of balance or consciousness because of dizziness in past 12 months * Bone or joint problem (for example, back, knee, or hip) that could be made worse by a change in physical activity. * Currently pregnant or planning on becoming pregnant in the next 3 months * Currently taking exogenous insulin * Previous heart attack or stroke * Any other reason that prevents ability to walk on a treadmill for 50 minutes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean 24 hour glucose levels (mmol/l) | 24 hours | Mean glucose assessed for 24 hours after walking or seated control assessed by continuous glucose monitoring |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Standard Deviation of Glucose Values | 24 hours | Standard deviation of glucose values assessed for 24 hours after walking or seated control assessed by continuous glucose monitoring |
| Post-dinner glucose control | 2 hours following dinner | Incremental area under the glucose curve for 2 hours following dinner |
| Mean amplitude of glycemic excursions (MAGE) | 24 hours | MAGE assessed for 24 hours after walking or seated control assessed by continuous glucose monitoring |
| Post-breakfast glucose control | 2 hour following breakfast | Incremental area under the glucose curve for 2 hours following breakfast |
| Time spent above 10 mmol/l glucose | 24 hours following walking or seated control | Time in minutes above 10 mmol/l assessed by continuous glucose monitoring over 24 hours |
| Post-lunch glucose control | 2 hours following lunch | Incremental area under the glucose curve for 2 hours following lunch |
Countries
Canada
Outcome results
None listed