Schizophrenia
Conditions
Brief summary
Schizophrenia is an invalidating psychiatric illness with a strong genetic component characterized by abnormal processing of emotional information. This alteration in emotion processing has been described in acute as well as in remission phases of the illness. It has also been found in healthy relatives of patients with schizophrenia and in subjects at high risk of psychosis. Thus, alterations in emotional information processing are not only linked to the prognosis but can also be considered as a marker of vulnerability of schizophrenia. In addition, schizophrenia patients differ from healthy controls in neural activity in brain regions implicated in emotions processing. However, interpretation of findings in patients is limited by confounding factors, such as antipsychotic treatments or alterations due to the course of illness. Also, there is no data concerning genetic factors (polymorphisms or gene expression) underlying these patterns of cerebral activation in emotion information processing. So, the main objective of this study is to compare the cerebral activity of schizophrenia patients to that of healthy siblings and healthy controls in an emotional processing task.
Interventions
GENETICPolymorphism (SNP in DNA)
GENETICquantitative measures of mRNA
OTHERNeuropsychological assessment
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Male or female participant, right-handed, aged from 18 to 45 years old * Haven given their written consent * DSM-5 (Diagnostic and Statistical Manual of Mental Disorders version 5) diagnosis of schizophrenia * Remitted phase (criteria of Andreasen) * Stable doses of antipsychotics during the last 6 weeks * No severe somatic illness * Normal clinical exam * Inscription to the social security
Exclusion criteria
* Women in genitally active period without contraception * Women pregnant or breast feeding * Participants presenting a severe somatic /neurologic condition * Present/history in the last year of alcohol or drug abuse * Participating in another clinical study or still in period of exclusion of a previous clinical trial * Contraindication to an MRI test (metallic foreign body, pacemaker, heart valve, chirurgical clip, claustrophobia…)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Oxygen Level dependent (BOLD) signal activity in Anterior Cingulate Cortex (ACC) measured by functional MRI | 4 hours |
Secondary
| Measure | Time frame |
|---|---|
| Description of whole brain neuro-anatomy based using Voxel Brain Morphometry (VBM) | 4 hours |
| Assessment of the functional connectivity in cortico-limbic circuit which underlie the emotional information using functional MRI | 4 hours |
| Quantitative expression of messenger Ribo Nucleic Acid (mRNA) in Peripheral Blood Mononuclear Cells (PBMC) | 4 hours |
| Polymorphism (single-nucleotide polymorphism SNP) of DNA (DeoxyriboNucleic Acid) | 4 hours |
Countries
France
Contacts
Primary ContactXavier ZENDJIDJIAN, Dr
Outcome results
None listed