Difference of Gastric Microbiota in the Process of Correa's Model.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02833363

Enrollment

Registered

2016-07-14

Start date

2016-07-31

Completion date

2017-02-28

Last updated

2016-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrophic Gastritis, Gastric Cancer, Gastric Microbiota, Helicobacter Pylori, Intestinal Metaplasia, Intraepithelial Neoplasia, Non-atrophic Gastritis

Keywords

gastric microbiota, Helicobacter pylori, Non-atrophic Gasrititis, Atrophic gastritis, Intestinal metaplasia, intraepithelial neoplasia, Gastric cancer

Brief summary

Helicobater pylori plays an important role in the development of gastric cancer. Eradication therapy can reducing the morbidity of gastric cancer, but can't totally prevent it especially when atrophy and more serious precancerous lesions already happened. Prior studies found the gastric bacterial difference among gastritis, intestinal metaplasia and gastric cancer. However, they didn't reach an agreement. Correa's model is widely accepted in the development of gastric cancer. The pathological change makes a more suitable environment for bacteria to overgrowth. This study are designed to analyze the gastric microbial difference of non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, intraepithelial neoplasia and gastric cancer.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1. Patients go through a gastric endoscopy examination with non-atrophic gastritis, atrophic gastris, intestinal metaplasia, intraepithelial neoplasia and gastric cancer. 2. Did not take any antibiotics,PPI,probiotics and chinese herbs in the past one month,and took less than one week in the past three months before the gastroscopy examination. 3. Sign the informed consent.

Exclusion criteria

1. Had been taken Helicobacter pylori eradication therapy before. 2. Previous gastrointestinal surgery. 3. During the pregnancy and lactation period. 4. With any serious diseases like liver failure,heart failure,renal failure,malignant tumor,alcoholism or any other disease that may effect the result. 5. With any mental problems.

Design outcomes

Primary

Measure	Time frame
Difference of Gastric Microbiota in the Process of Correa's Model.	5 months

Secondary

Measure	Time frame
Difference of Gastric Microbiota in the Process of Correa's Model.	5 months

Countries

China

Contacts

Primary ContactYanqing Li, MD,PHD

liyanqing@sdu.edu.cn86-531-82169236

Outcome results