Healthy
Conditions
Keywords
blood pressure, heart rate variability, single-pulse transcranial magnetic stimulation, non-invasive brain stimulation
Brief summary
The purpose of this study is to determine the effects of TMS on the ANS. The investigator will determine whether single-pulse TMS of the primary motor cortex in the dominant hemisphere in healthy, young adults will affect 1) heart rate and heart rate variability, 2) blood pressure and 3) baroreflex function. This study is foundational in that it will begin to characterize how single-pulse TMS affects the ANS in healthy adults.
Detailed description
The overall purpose of this study is to investigate the effects of TMS on the ANS. Specifically; the investigator aim to determine if single-pulse TMS of the primary motor cortex in the dominant hemisphere in healthy, young adults will significantly affect 1) heart rate and heart rate variability, 2) blood pressure and 3) baroreflex function. The first purpose of this study is to measure alterations in sympathetic and parasympathetic activation in response to TMS. To do this, we will measure HRV immediately after single-pulse TMS. The second purpose is to investigate the changes in blood pressure in response to TMS and to determine whether the baroreflex, a critical modulator of blood pressure, is inhibited by TMS. Aim 1: To determine if single-pulse TMS of the primary motor cortex will significantly alter heart rate variability. We hypothesize that single-pulse TMS of the primary motor cortex will elicit an acute decrease in heart rate and result in improved heart rate variability indicated by a significantly decreased LF power and increased HF power. Aim 2: To determine if single-pulse TMS of the primary motor cortex will significantly alter blood pressure and baroreflex sensitivity (BRS). We hypothesize that single-pulse TMS of the primary motor cortex will elicit an acute decrease in blood pressure by inhibiting the baroreflex.
Interventions
Single-pulse Transcranial Magnetic Stimulation activates neurons within the cortex of the brain by way of electromagnetic induction. This causes a small, focused electric field to become present in the brain, which activates the neurons.
Sponsors
University of Minnesota
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers between 18-65 years old
Exclusion criteria
* pregnant or breastfeeding women * previous episodes of seizures or fainting * any implanted metal in their head * history of migraines * history of psychiatric disorder (e.g. depression, anxiety, ADHD, bi-polar disorder) * currently taking medications that may alter autonomic function (e.g. blood pressure medication, depression medication)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Blood Pressure during the intervention as compared to baseline | Change from baseline | It is possible that blood pressure is changing when the single-pulse transcranial magnetic stimulation is being delivered. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Heart Rate Variability from baseline | Change from baseline | Heart rate variability is a non-invasive measurement of the activity of the parasympathetic nervous system |
Countries
United States
Outcome results
None listed