Prostatic Neoplasms
Conditions
Brief summary
The primary purpose of this study is to investigate the effect of intravenous magnesium on blood pressure after Trendelenburg position during robot assisted prostatectomy. The secondary purpose of this study is to investigate the effect of intravenous magnesium on pain after robot assisted prostatectomy.
Interventions
DRUGMagnesium Sulfate
adminstration of intravenous magnesium as bolus of 50 mg/kg, followed by continuous infusion at rate of 10 mg/kg/h
DRUGNormal saline
the same bolus and infusion volumes of normal saline
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
60 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Robot assisted prostatectomy
Exclusion criteria
* Allergy to magnesium * Chronic pain * Chronic opioid use * Chronic NSAID use * Renal dysfunction * Liver dysfunction * Cardiac arrythmia * Seizure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean blood pressure | Up to 2 hours after Trendelenburg position |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain | Up to 24 hours after surgery end | pain assessment using visual analog scale |
Countries
South Korea
Outcome results
None listed