Obesity
Conditions
Keywords
Overweight, Molecular hydrogen, Insulin
Brief summary
Molecular hydrogen (H2) effectively tackles obesity-related disorders in animal models yet no studies so far investigated the effectiveness of H2 for improving biomarkers of obesity in humans. In this double blind, placebo-controlled, crossover pilot trial, the investigators will evaluate the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in middle age overweight women, with hydrogen administered orally for 4 weeks.
Interventions
DIETARY_SUPPLEMENTMolecular hydrogen
DIETARY_SUPPLEMENTPlacebo
Sponsors
Center for Health Sciences, Serbia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
55 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age \> 55 years * body mass index \> 25 kg/m2
Exclusion criteria
* no history of H2 supplementation within the 4 weeks before study commenced * no major chronic diseases, as evaluated by pre-participation health screening and clinical chemistry
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body fat percentage change | Baseline vs. four weeks | Baseline vs. four weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum insulin change in IU/mL | Baseline vs. four weeks | Baseline vs. four weeks |
Other
| Measure | Time frame | Description |
|---|---|---|
| Serum ghrelin change in IU/mL | Baseline vs. four weeks | Baseline vs. four weeks |
Countries
Serbia
Outcome results
None listed