Aging
Conditions
Brief summary
The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.
Interventions
OTHERMRI
Perform MRI studies
OTHERGroup 4
Perform MRI studies
Sponsors
University of Minnesota
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
21 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. English-speaking as primary language 2. No hearing loss or uncorrected vision
Exclusion criteria
1. Lacking capacity to consent 2. Having known history of cardiovascular diseases (e.g., clinical stroke) 3. Having acute and chronic obstructive pulmonary disease 4. Having known history of renal diseases (e.g., acute kidney injury) 5. Having known history of cognitive disorder or psychiatric illness 6. Having known history of chemical dependence (e.g., alcohol and narcotics) 7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI measured perfusion for each group | Baseline | MRI measurements will be summarized for each group by using mean and standard deviation or standard error. |
| MRI measured vascular reactivity for each group | Baseline | MRI measurements will be summarized for each group by using mean and standard deviation or standard error. |
| Cognitive performance for each group | Baseline | The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error. |
Countries
United States
Contacts
Primary ContactXiufeng Li, Ph.D.
Outcome results
None listed