Encephalopathy
Conditions
Keywords
prematurity
Brief summary
The purpose of this study is to explore the perinatal risk factors of encephalopathy of prematurity and the morbidity of the following neurodevelopmental impairments in preterm infants with gestational age \<32 weeks in China.
Detailed description
Recent years have witnessed an increase in survival of very or extremely low birth weight infants, with a corresponding increase of attention to encephalopathy of prematurity (EOP) and the following neurological disorders. Studies suggested that hypoxic-ischemic injury and perinatal infection might be the two main risk factors of EOP, including white matter injury, neuronal-axonal diseases and cerebellar hemorrhage, which have a strong impact on neurological outcomes. Sequelae like cerebral palsy or mental retardation become a burden to both the family and society. Therefore, the risk factors of brain injury become the critical issue of both Obstetrics and Neonatology. More importantly, little is known about the morbidity of neurodevelopmental impairment and its risk factors in China. Thus, the aim of our study is to explore the perinatal risk factors of encephalopathy of prematurity and the morbidity of the following neurodevelopmental impairments in preterm infants with gestational age \<32 weeks in China.
Interventions
None listed
Sponsors
Children's Hospital of Fudan University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 28 Days
Healthy volunteers
No
Inclusion criteria
* preterm infants with gestational age less than 32 weeks
Exclusion criteria
* major congenital malformations * chromosomal disorders * metabolic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| developmental quotient (DQ) on the Gesell Developmental Schedules | 2 years | Result of gross motor, fine motor, language and social test. DQ = Development Age / Chronological Age X 100 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| brain injury showed on MRI | 36-40 weeks' postmenstrual age or before discharge | signal abnormality in white matter, grey matter or cerebellum injury; periventricular leukomalacia; intracranial hemorrhage |
| morbidity of encephalopathy of prematurity | 36-40 weeks' postmenstrual age or before discharge | white matter injury, grey matter injury, cerebellum injury on MRI |
| all cause mortality | 2 years | Mortality that does not require judgments about the cause of death |
| neurodevelopment sequelae | 2 years | including cerebral palsy, epilepsy, hearing loss, vision loss, etc. |
Countries
China
Outcome results
None listed