Aging, Cognitive Impairments
Conditions
Brief summary
A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. Although it is still unknown what triggers AD, recent studies have shown that AD is associated with brain energy depletion, oxidative stress, and mitochondrial dysfunction. Since supplemental molecular hydrogen (H2) supports cell energy production and acts as a highly bioavailable mitochondria-related antioxidant, it may provide an ideal agent to facilitate treatment and perhaps prevention of AD and similar cognitive disorders in elderly. The overall hypothesis to be evaluated in this project is that administration of H2 will positively affect patient-reported outcomes and clinical biomarkers in men and women suffering from AD.
Interventions
OTHERMolecular Hydrogen
Sponsors
University of Novi Sad, Faculty of Sport and Physical Education
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age over 65 * No psychiatric comorbidities
Exclusion criteria
* Use of dietary supplements 4 weeks before study commence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ADAS-Cog score for cognitive function | Change from Baseline ADAS-Cog Score at 4 weeks | ADAS-Cog total score and scores for 4 separate cognitive domains (memory, orientation, praxis, and language) will be evaluated. |
Countries
Serbia
Outcome results
None listed