Potentially Inappropriate Prescription Associated to Multimorbidity

Conditions

Chronic Disease

Keywords

Multimorbidity, Polypharmacy, Appropriateness, STOPP, START

Brief summary

A prospective multicenter cohort study in 5 hospitals in Spain will be initiated in 2016. Objectives: 1. To estimate and describe patterns of multimorbidity and polypharmacy in patients over 64 admitted for a chronic disease exacerbation. 2. To analyze the potentially inappropriate prescribing (PPI) drugs according to STOPP / START (SS) criteria. 3. To evaluate the relationship between multimorbidity and PPI and adverse medication (RAM) preventable reaction. The cohort will include 800 patients \>64 years admitted in internal medicine and / or geriatric department of 5 hospitals of the National Health Service. Application of the SS criteria (released in 2015) on admission and at discharge, and collection of demographic and clinical variables including comorbidities, baseline chronic medication, geriatric syndromes, functional capacity and RAM. Descriptive analysis and bivariate parametric or nonparametric tests will be applied to analyze relationship between morbidity, polypharmacy, SS criteria and RAM. Intraobserver agreement will be assessed for SS criteria. Multiple regression techniques will be applied, where the dependent variable will be the PPI or the RAM.

S Ortonobes Roig, Susana Herranz, Marina Lleal, Daniel Sevilla‐Sánchez, R. Jordana et al. (28 authors)

BMC Geriatrics2024-07-081 citations

10.1186/s12877-024-05185-w

Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study

Marina Lleal, Marisa Baré, S Ortonobes Roig, Daniel Sevilla‐Sánchez, R. Jordana et al. (13 authors)

International Journal of Environmental Research and Public Health2022-11-294 citations

10.3390/ijerph192315902

Factors associated to potentially inappropriate prescribing in older patients according to STOPP/START criteria: MoPIM multicentre cohort study

Marisa Baré, Marina Lleal, S Ortonobes Roig, María Queralt Gorgas, Daniel Sevilla‐Sánchez et al. (9 authors)

BMC Geriatrics2022-01-1142 citations

10.1186/s12877-021-02715-8

Multimorbidity patterns of chronic conditions and geriatric syndromes in older patients from the MoPIM multicentre cohort study

Marisa Baré, Susana Herranz, Albert Roso‐Llorach, R. Jordana, Concepción Violán et al. (10 authors)

BMJ Open2021-11-0140 citations

10.1136/bmjopen-2021-049334

Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM

Marisa Baré, Susana Herranz, R. Jordana, María Queralt Gorgas, S Ortonobes Roig et al. (9 authors)

BMJ Open2020-01-0120 citations

10.1136/bmjopen-2019-033322

Interventions

OTHERNo intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Patient admitted to the Internal Medicine or Geriatrics department * Admitted to hospital because of an exacerbation of any previous chronic condition

Exclusion criteria

* Terminal ill patients at admission * Patients with lower forecast life than 1 year * Patient admitted to the hospital only because an acute problem * In patient home care

Design outcomes

Primary

Measure	Time frame
Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria	At study entry

Secondary

Measure	Time frame	Description
Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria	Through study completion, an average of 2 years	—
Percentage of patients with polypharmacy	At study entry	Polypharmacy=more than 5 chronic medications
Patients with any treatment-related adverse events (ADR), according to the Wills & Brown classification	Through study completion, an average of 2 years	—
Percentage of different Patterns of multimorbidity in chronic patients, according to clusters or associations of different chronic conditions	At study entry	—

Countries

Spain

Outcome results

None listed