Intubated Brain Injured
Conditions
Keywords
Intensive care unit, Neuro-ICU, Pain, Intubation, critical care, patients
Brief summary
Nociception in intensive care unit is frequently evaluated with some tools such as BPS (Behavioral Pain scale) and NCS (Nociception coma scale). These scales were not validated in intubated and brain injured ICU patients. The investigators propose to validate the NCS adapted for intubated patients (NCS-I) in comparison with the recommended scale (BPS) and the Pupillary response (videopupillometry) to noxious stimulation (common procedure of care).
Detailed description
Nociception in intensive care unit is frequently evaluated with some tools such as BPS (Behavioral Pain scale) and NCS (Nociception coma scale). These scales were not validated in intubated and brain injured ICU patients. The investigators propose to validate the NCS adapted for intubated patients (NCS-I) in comparison with the recommended scale (BPS) and the Pupillary response (videopupillometry) to noxious stimulation (common procedure of care).
Interventions
OTHERNCS-I (Nociception Coma Scale adapted intubated patients)
Every included patient will be assessed by the 3 methods 3 times (before, during, after the procedure fo care) in 3 conditions. There will be 2 painful conditions usually performed in ICU (Nursing and bronchoaspiration) and a painless condition (RASS assessment).
Sponsors
University Hospital, Montpellier
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Adult, \> or equal to 18-yr * Admission to intensive care unit * Brain injured and intubated patient * Signs of awakening after the interruption of sedation * Impossibility to self-report pain intensity
Exclusion criteria
* Eye injuries (glaucoma, keratitis, conjunctivis, cataract) * Neurodegenerative attack * Brainstem damage * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in pain scores or pupillary diameter measures at rest and during care procedures | Through study completion (30 months) | Discriminant validity between NCS-I, BPS and pupillary measurements will follow current recommended method for psychometric assessment of pain tools in critical care patients (Pain Agitation and Delirium Guidelines from the Society of Critical Care Medicine, Barr et al. Crit Care Med 2013). Mann-Whitney-Wilcoxon test will be used to compare values obtained at rest and during the procedures of care. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weight kappa coefficient for pain using the NCS-I | Through study completion (30 months) | Reliability of NCS-I and BPS will follow current recommended method for psychometric assessment of pain tools in critical care patients (Pain Agitation and Delirium Guidelines from the Society of Critical Care Medicine, Barr et al. Crit Care Med 2013). |
| Weight kappa coefficient for pain using the BPS | Through study completion (30 months) | Weighted kappa coefficient will be used to measure inter-observers agreement using the two subjective pain scales (NCS-I and BPS). |
Countries
France
Outcome results
None listed