Anesthesia
Conditions
Brief summary
The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.
Detailed description
Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different bispectral index values. However, the difference between analgesic effects of volatile anesthetics have not yet been investigated. The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index-guided remifentanil infusion.
Interventions
DRUGSevoflurane
End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period. The remifentanil infusion rate was adjusted using TCI pump to achieve surgical pleth index between 20 and 50.
DRUGDesflurane
End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period. The remifentanil infusion rate was adjusted using TCI pump to achieve surgical pleth index between 20 and 50.
Sponsors
Kangbuk Samsung Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing balanced general anesthesia using volatile anesthetics and remifentanil * patients with american society of anesthesiologist physical status I, II * patients aged 19-65 years * patients obtaining written informed consent
Exclusion criteria
* patients with a history of any psychiatric or neurological disease * patients who had received any medication affecting the central nervous system * patients who had received medication affecting the sympathetic or parasympathetic nervous systems * patients undergoing tracheal intubation for airway management * pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remifentanil consumption (µg/kg/min) | During the intraoperative period |
Secondary
| Measure | Time frame |
|---|---|
| Target effective site concentration of remifentanil (ng/ml) | After at least 10 min of stable surgical pleth index values |
Countries
South Korea
Outcome results
None listed