Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects

Effects of Non-surgical Treatment of Chronic Periodontitis on Insulin Resistance and Glucose Tolerance in Non-diabetic Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02830113

Acronym

PARODIA2

Enrollment

Registered

2016-07-12

Start date

2014-12-31

Completion date

2015-09-30

Last updated

2016-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Prediabetes

Keywords

periodontitis, diabetes, prevention, impaired glucose tolerance, insulin resistance

Brief summary

This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.

Detailed description

Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.

Interventions

PROCEDUREnon-surgical periodontal treatment

One session of complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Chronic periodontitis * Non diabetic individual

Exclusion criteria

* Known diabetes * Periodontal treatment less than 6 months prior to inclusion * Having less than 20 natural teeth

Design outcomes

Primary

Measure	Time frame	Description
Glucose tolerance	3 months	change in 2-hour post load blood glucose
Insulin sensitivity	3 months	change in glucose disappearance rate during the short insulin tolerance test

Secondary

Measure	Time frame	Description
Composite periodontal health	3 months	Change in plaque index, gingival bleeding index, pocket depth, and clinical attachment loss
Inflammation	3 months	change in Serum CRP

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026