Autonomic Nervous System Diseases, Sleep
Conditions
Keywords
autism spectrum disorder
Brief summary
Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder which involves social and behavioural impairments. Autonomic dysfunctions and disturbed sleep were often associated to ASD. The investigators proposed to explore the impact of physical activity on these disorders. In this context, it is necessary to characterize the cardiorespiratory capacities of ASD children in order to promote physical activity for this population. To examine potential differences between ASD and control children, some explorations were proposed: a maximal treadmill test, motor evaluation, and orthostatic test (for the evaluation of autonomic nervous system). An actimetry during one week (evaluation of physical activity and sleep) completed this study in order to specify sleep characteristic and established the possible link between physical activity sleep characteristics and physical fitness in ASD children.
Interventions
OTHERphysiological explorations
Sponsors
University Hospital, Grenoble
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* children physically active * children with an intellectual quotient \>70 * for autism children a diagnosis of autism in accordance to DSMV
Exclusion criteria
* history of cardio-vascular disease * history of asthma or respiratory disease * Behavior disorders. * medical treatment by neuroleptic or melatonin or antiepileptic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiorespiratory evaluation | 1 day | a maximal treadmill test is proposed (evaluation of : VO² max, maximal heart rate) |
| autonomic nervous system evaluation | 1 day and 3 nights | an orthostatic test is proposed in order to verify the ANS adaptation. A nocturnal recording is made during three nights in order to verify the possible link between the rest autonomic adaptations and a possible dysautonomia observed with the orthostatic test. |
| sleep evaluation | 7 nights | Sleep characteristics are obtained by an actimetry during 7 nights in order to observe sleep disorders. Sleep Questionnaires are also completed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| physical activity | 7 days | physical activity characteristics (sedentary, moderate or vigorous activities, energy expenditure) are obtained by an actimetry during 7 days. Questionnaires of physical activity are also completed |
| biological parameters | 1 day | during the maximal treadmill test, salivary samples are made (cortisol, alpha amylase), before and after tthe test |
| Motor capacities | 1 day | motor capacities are evaluated by several specific tests : PANESS, M-ABS and Eurofit. |
| Behavioural characteristics | 1 hour | Behavioural characteristics are evaluated by the Vineland scale |
Countries
France
Outcome results
None listed