Colorectal Peritoneal Carcinomatosis
Conditions
Keywords
Digestive peritoneal carcinomatosis, laparoscopy, laparotomy, peritoneal cancer index (PCI), staging
Brief summary
The peritoneum is the second most common site of recurrence in patients with colorectal cancer. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improve the prognosis of these patients and incorporates surgical removal of all visible disease followed by chemical destruction of microscopic disease through chemoperfusion. The most validated predictors of outcome are preoperative tumor burden measured in terms of the peritoneal carcinomatosis index (PCI) and completeness of cytoreduction (CC score). Diagnostic laparoscopy prior to resection is widely used in hepatopancreaticobiliary and colorectal cancer and has been shown to be effective in excluding unnecessary laparotomy associated with higher morbidity.
Interventions
OTHERNon interventional
Peroperative data collection
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with Colorectal cancer with a resected minimal synchronous peritoneal carcinomatosis, or ovarian metastases, tumour rupture in the abdominal cavity. * Patients received six months of systemic chemotherapy (currently the Folfox-4 regimen which could be modified if the standard is modified)
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peritoneal carcinomatosis staging | during laparoscopy and during laparotomy (Day 1) | To score the Collect detailed detailed Peritoneal Cancer Index (PCI) by laparoscopy following the laparotomy procedure in order to evaluate the accuracy and adequacy of laparoscopic surgical staging comparing to laparotomic approach. |
Countries
France
Contacts
Primary ContactOlivier GLEHEN, Prof
Backup ContactPeggy JOURDAN-ENFER
Outcome results
None listed