Sickle Cell Disease
Conditions
Keywords
endothelial function, flow-mediated dilation, vascular elastic properties
Brief summary
Sickle cell disease (SCD) is an inherited disorder characterized by recurrent painful crises with ischemia resulting from vascular occlusion. Adults with SCD have increased arterial stiffness and reduced flow-mediated dilation (FMD), due to impaired release of substances such as nitric oxide. The present study assess the vascular properties of carotid and brachial arteries in children with SCD compared with a control group without cardiovascular risk factors.
Interventions
PROCEDUREEchocardiography
Measures by Doppler and study of endothelial function
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
7 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
Sickle cell group : * Children with sickle cell syndrome (SS or SC) * Children hospitalized in the hematology unit (day hospital) * The girls set must have had a negative pregnancy test. * One of the two holders of parental authority must have signed consent form * Children affiliated to a social security scheme or equivalent Control group : Children recruited in a previous study : * Holders of parental authority affiliated to a social security scheme * Children recruited during the balance of a heart murmur or a vasovagal reaction * Children whose cardiological examination is normal * Children having no cardiovascular risk factor
Exclusion criteria
Sickle cell group : * Children with intercurrent diseases such as obesity, intra uterine growth retardation (IUGR), hypertension, renal failure, infectious diseases (including HIV, Hepatitis C) or chronic inflammatory * Children who have sickle cell crisis there is less than 1 month. Control group : Children with intercurrent diseases: obesity, IUGR, hypertension, renal failure, infectious diseases (including HIV, Hepatitis C) or chronic inflammatory
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of endothelial function | baseline | Evaluation parameter of endothelial function (brachial artery): flow dependent dilatation (expressed in%) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| match the measurement thickness of the intima media | baseline | The thickness of the intima media (ITM) on the right common carotid |
| match the measurement systolic and diastolic diameters | baseline | systolic and diastolic diameters (sD, dD) |
| distensibility cross sectional | baseline | match the measurement on the compliance and distensibility cross sectional (CCS, DCS) |
| Match the measurement on the diastolic wall stress | baseline | diastolic wall stress (DWS) |
Countries
France
Outcome results
None listed