Ischemia
Conditions
Keywords
cerebral ischemia
Brief summary
The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI
Interventions
PROCEDURECerebroSpinal fluid and plasma samples
CerebroSpinal fluid and plasma samples for biological markers
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended * symptomatic aneurysm treated with endovascular, * Absence of achieving a lumbar puncture, * Patients affiliated to a social security scheme, * Patients who have given their free and informed consent and signed the consent or consent of the family. Group 2 : healthy volunteers with cerebrospinal fluid sample
Exclusion criteria
* Patients with no readable acoustic temporal bone window * Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| delayed cerebral ischemia | inclusion | DCI was confirmed by CT or MR imaging |
Countries
France
Outcome results
None listed