Graft-versus-host Disease Associated Myelosuppression

Functional Profiling of the Hematopoietic Stem Cell Niche in Graft Versus Host Disease Mediated Bone Marrow Insufficiency

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02829216

Enrollment

Registered

2016-07-12

Start date

2016-04-30

Completion date

Unknown

Last updated

2016-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormal Hematopoiesis, Allogenic Disease, Graft vs Host Disease

Keywords

myelosuppression, mesenchymal stromal cells

Brief summary

The objective is to measure the frequency, functionality and phenotype of bone marrow-derived mesenchymal stromal cells in patients after allogeneic hematopoietic stem cell transplantation. Furthermore, the immune cell infiltrate of the bone marrow will be monitored at the same time. These results will be correlated with the extent of cytopenia and clinical graft-versus-host disease grading.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* age \>18 * acute myeloid leukemia * myelodysplastic syndrome * hematopoietic stem cell transplantation

Exclusion criteria

* not willing to take part

Design outcomes

Primary

Measure	Time frame
Changes in the amount of mesenchymal stromal cells after allogeneic hematopoietic stem cell transplantation	up to 1 year after allogeneic hematopoietic stem cell transplantation

Countries

Germany

Contacts

Primary ContactMalte von Bonin, MD

malte.bonin@uniklinikum-dresden.de00493514586636

Outcome results