Drug Exposition
Conditions
Keywords
Benzodiazepines, Fracture
Brief summary
The question of the inclusion of periods of interruptions and periods unobservable has been studied as part of medico-administrative databases. However, the specificity of the health insurance databases justify the realization of dedicated methodological research. A thorough knowledge of the purpose of these data, how they collect and restitution is an essential prerequisite to carry out this work. One type of scheme cohort exposed/unexposed led to the formulation of a finding on the basis of the comparison between the exposure groups. However, this traditional approach has the major drawback of neglecting the changing nature of drug exposure, and therefore fails to take into account any changes or interruptions doses. Approaches to take into account the time dependent variables were developed. These allow to take into account any interruptions. However, as part of study on health databases, sometimes we do not have the status in relation to the exhibition on the entire monitoring period. This is for example the case during hospitalization. The bias generated by the failure to take account of these periods (non measurable time bias) can be problematic when a long exposure and chronic disorders require hospitalization.
Interventions
OTHERMedical consultation without prescription
Medical consultation without prescription of any drugs of interest
OTHERExposition to hypnotics or anxiolytics benzodiazepines
Exposition to at least one drug belonging to the following classes during the last 12 months before index date : * Benzodiazepine derivatives (N05BA) * Benzodiazepine derivatives (N05CD) * Benzodiazepine related drugs (N05CF)
OTHERExposition to non benzodiazepines antidepressants, hypnotics or anxiolytics
Exposition to at least one drug belonging to the following classes during the last 12 months before index date : * Antipsychotics (N05A) * Antiepileptics with the exception of clonazepam (N03) * Drugs used for alcohol dependance (N07BB) * Drugs used for opioids dependance (N07BC)
OTHERAdministrative and medical data
* Gender * Birthdate * Department of residence * City of residence * Vital status (month and date of death) * Affiliation to Universal Health Coverage * Number of chronic long-term illness, medical diagnostic or pathology (CIM 10 code), onset and end dates * Drugs reimbursements (Date of care onset, drugs identification code, number of box delivered) * Data collected from medicalisation program of information system and private and public home care structures * Medical consultations, medical acts ( Common Classification of Medical Acts nomenclature)
Sponsors
University Hospital, Toulouse
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
General Inclusion Criteria: * Beneficiaries of all social security regimen with a minimum of one year of data in general sample of beneficiaries Group expose to benzodiazepine : * Exposition to at least one benzodiazepine or anxiolytic Group antidepressants and anxiolytics and hypnotics non benzodiazepines : * Exposition to at least one antidepressants and anxiolytics and hypnotics non benzodiazepines Control group : \- Patient having a medical consultation without prescription of interest
Exclusion criteria
* Non incident patient : Patient having a prescription of benzodiazepines, clonazepam, tetrazepam, antidepressants, anxiolytics ou hypnotics non benzodiazepine during the last 12 months before index date
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of mortality from all causes in the 3 groups as assessed by clinical data collected | through the end of study (12 months) | Four approaches will be used : * intergroup comparison * Time influence with cox model * Use of markovian models * Inclusion of non observable periods with inobservable and observable death models |
Outcome results
None listed