Effect of Anesthesia on Quality of Recovery in Patients Undergoing Correctional Tibial Osteotomy - A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02826902

Enrollment

Registered

2016-07-11

Start date

2016-09-27

Completion date

2019-11-09

Last updated

2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Short Stature, Osteoarthritis

Keywords

Total intravenous anesthesia, desflurane, QoR-40, correctional tibial osteotomy

Brief summary

The effect of total intravenous anesthesia (TIVA) versus inhalational anesthesia on the quality of recovery from surgery has been reported in several different types of operations. The Quality of Recovery 40 (QoR-40) questionnaire is designed multi-dimensionally to assess the degree of recovery after anesthesia and surgery, and has been validated in previous studies. The present study aims to compare the quality of recovery with the QoR-40 questionnaire, in patients undergoing correctional tibial osteotomy under general anesthesia with either TIVA with propofol or inhalational anesthesia with desflurane.

Interventions

DRUGpropofol and remifentanil

Anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil

DRUGdesflurane and remifentanil

Anesthesia is induced and maintained with desflurane and remifentanil

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

1\. Adult patients over the age of 19 scheduled for cosmetic lower limg lengthening for short stature, or correctional tibial osteotomy for osteoarthritis

Exclusion criteria

1. Patient refusal 2. Patients with altered mental status 3. Ejection fraction under 55% 4. Recent MI, CVA, or major cardiovascular surgery 5. 3rd degree AV block, 2nd degree AV block with P:QRS ration greater than 3:1 6. Hemodynamically unstable patients requiring vasopressors or oxygen therapy 7. Febrile patients 8. Patients with decreased renal function (serum Cr \> 0.1 mg/dL) 9. Patients with known allergies to propofol 10. Pregnant patients

Design outcomes

Primary

Measure	Time frame
QoR-40 score	24 hours after surgery

Secondary

Measure	Time frame
QoR-40 score	preoperative period to 48 hours after surgery

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026