Prehypertension, Hypertension Stage 1
Conditions
Brief summary
The purpose of the trial is to evaluate the effect of Djulis-Buckwheat drink on cardiovascular protection after ingesting for 8 weeks. In addition, the correlation between the supplement and the cardiovascular disease-related gene expression is evaluated. The results will be used for the application of functional products for cardiovascular protection. Ninety subjects (age 30\ 65) with Prehypertension or Hypertension stage 1 will be included and randomly allocated into 3 groups: Placebo, Djulis-Buckwheat and Buckwheat. The subjects will take sample (100 ml/day) for 8 weeks. Blood pressure will be measured on week 0, 1, 2, 4, 6 and 8. The blood biochemical parameters and gene expression analysis will be examined on week 2, 4, 6, 8 and 10 (the follow up).
Interventions
DIETARY_SUPPLEMENTPlacebo
Ingest placebo drink 100ml/day for 8 weeks
DIETARY_SUPPLEMENTDjulis-Buckwheat
Ingest Djulis-Buckwheat drink 100ml/day for 8 weeks
DIETARY_SUPPLEMENTBuckwheat
Ingest Buckwheat drink 100ml/day for 8 weeks
Sponsors
Taipei Medical University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Systolic blood pressure 121-159 mmHg or Diastolic blood pressure 81-99 mmHg * Age: 30-65
Exclusion criteria
* Have diagnosed and documented critical illness(NHI specification) * Had emergency record or admission note in the past three months * Not be pregnant or breast-feeding a child
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of blood pressure | Baseline, 1, 2, 4, 6, and 8 weeks |
Outcome results
None listed