Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions

Effect of Amino Acids and Sugar Alcohols on Release of Satiation Peptides and Activation of Specific Brain Regions in Normal Weight and Obese Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02823249

Enrollment

Registered

2016-07-06

Start date

2014-05-31

Completion date

2015-04-30

Last updated

2017-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endocrine System Diseases

Brief summary

With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.

Interventions

DIETARY_SUPPLEMENT1.56 g L-Tryptophan

DIETARY_SUPPLEMENT1.56 g L-Leucine

DIETARY_SUPPLEMENT50 g Xylitol

DIETARY_SUPPLEMENT75 g Erythritol

DIETARY_SUPPLEMENT75 g Glucose

DIETARY_SUPPLEMENTTap water

DIETARY_SUPPLEMENTMixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

DEVICENasogastric Tube

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy normal weight subjects with a body-mass index of 19.0-24.9 * Healthy obese subjects with a body-mass index of \> 30 * Normal eating habits (no diets; no dietary changes; no special dietary habits such as vegetarian/vegan) * Age 18-40 years * Stable body weight for at least three months

Exclusion criteria

* Smoking * Substance abuse * Regular intake of medications (except for oral contraceptives) * Medical or psychiatric illness * History of gastrointestinal disorders * Food allergies * Pregnancy, breast feeding * Body piercings that cannot be removed * History of claustrophobia * Left-hander

Design outcomes

Primary

Measure	Time frame
Effect of aminoacids on cerebral blood flow measured by functional brain MRI	changes from baseline to one hour after treatment
Effect of sugar alcohols on cerebral blood flow measured by functional brain MRI	changes from baseline to one hour after treatment

Secondary

Measure	Time frame
Measurement of Plasma cholecystokinin concentrations	changes from baseline to three hours after treatment
Measurement of Plasma Glucagon-like Peptide (GLP-1) concentrations	changes from baseline to three hours after treatment
Measurement of Plasma Glucose concentrations	changes from baseline to three hours after treatment
Measurement of Plasma ghrelin concentrations	changes from baseline to three hours after treatment
Measurement of Plasma PYY concentrations	changes from baseline to three hours after treatment
Measurement of Plasma Insulin concentrations	changes from baseline to three hours after treatment

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026