Acute Leukemia, Invasive Fungal Infection
Conditions
Brief summary
The aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.
Interventions
BIOLOGICALblood sample
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
: * persons who have provided written consent * Patients with national health insurance cover * Patients with malignant hemopathy who have been treated with chemotherapy able to induce profound neutropenia (PN \< 500 / mm3) lasting more than 10 days. * Patients with malignant hemopathy who have received an autologous bone marrow graft * Patients with severe idiopathic medullar aplasia (PN \< 500 / mm3) who need to be hospitalized for at least 10 consecutive days (with or without treatment with immunosuppressants)
Exclusion criteria
* Patients who have received an bone marrow PSC allograft (as such patients have a risk of aspergillosis, which appears in most cases after medullar recovery; they will not be included in the study). * Patients who have received an autologous PSC graf (as the duration of neutropenia is in most cases less than 10 days). * Patients whose neutropenia, retrospectively assessed, lasted less than 10 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum level of Mannose Binding Lectin (MBL) in patients with acute leukemia | 1st day of the period of aplasia |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of MBL during an episode of aplasia for both groups of patients studied | Every day except Saturday and Sunday for roughly 3 weeks |
Countries
France
Outcome results
None listed