One-lung Ventilation During Internal Thoracic Artery Grafting in Cardiac Surgery

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02823054

Acronym

VUPPAM

Enrollment

Registered

2016-07-06

Start date

2017-01-03

Completion date

2022-03-01

Last updated

2026-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass

Keywords

elective surgery, CABG, One-lung ventilation, EZ Blockers, pleural effusion

Brief summary

Coronary artery bypass grafting is a current cardiac surgery. Internal thoracic artery is usually taking to restore coronary revascularization, and its dissection can lead to accidental or voluntary pleural effusions. Respiratory complications are frequent, due to the drainage required. In this study, the investigators propose one-lung ventilation to facilitate artery grafting and surgical procedure. The investigators will include all adult patients with elective coronary artery bypass surgery (CABG) by internal thoracic artery, in a prospective, controlled, randomized and monocentric study. The main objective is to demonstrate that one-lung ventilation using EZ-Blocker can reduce pleural effusion defined by presence of drainage and/or pneumothorax on X-ray chest in the ICU.

Interventions

DEVICEEZ-Blocker

the Blocker group, the EZ-Blocker will be set up after anesthesia induction and standard orotracheal intubation to allow lung exclusion during homolateral internal thoracic artery sampling, and thus a one-lung ventilation. This material will be removed at the end of surgical surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* elective CABG surgery with internal thoracic artery, with patient consent. * Patient who have french social security

Exclusion criteria

* Cardiac or thoracic past-history * polyurethane allergy * guardianship patient * endotracheal intern diameter too small to allow the EZ-Blocker introduction or the fiberscope * use of LASER immediately near the EZ-Blocker

Design outcomes

Primary

Measure	Time frame	Description
Pleural effusions after coronary artery bypass graft surgery	Day 0	quantifying the number of thoracic drains (0, 1 or 2), as accidental or voluntary pleural effusion
absence of pneumothorax	Day 0	verify the absence of pneumothorax to X-ray chest ( not drained pleural effusion).

Countries

France

Contacts

PRINCIPAL_INVESTIGATORMathieu GUILBART, PhD

CHU Amiens

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 13, 2026