Auto-Immunity, Q Fever
Conditions
Brief summary
The IHU Mediterranean infection is national reference centre for Q fever. Coxiella burnetii is the bacteria responsible of this infection. The bacterium Coxiella burnetii infection is associated with secretion by the body both many antibodies against the bacteria but also against certain cells of the body (autoantibodies). These autoantibodies may have no effect or be associated with specific symptoms. Anti-Phospholipid antibodies are especially prevalent in the Q fever. Apart from this infection, they are associated with thrombocytopenia, obstetric complications, thrombosis and heart valve damage. These conditions have also been described as complications during Q fever. In a retrospective preliminary work on Q fever, we have shown that the presence of high levels of IgG anti-cardiolipin was associated with the presence of valvular and the evolution to endocarditis. Such associations have a therapeutic involvement and must therefore be confirmed. Indeed, if these associations were confirmed, a trans-esophageal ultrasound could be systematically proposed to patients with valvular disease of trans-thoracique ultrasound but IgG anticardiolipin high levels. Other special attention could be given to patients with high autoantibodies.
Interventions
BIOLOGICALBlood sampling
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a current or former Q fever diagnosis * Patient \> or = 18 years old. * Patient who does not declined to have his medical records reviewed for research. * Patient with health insurance.
Exclusion criteria
* Minor patient (\<18 years ) * Adult patient under guardianship . * Patient deprived of liberty or judgment. * Patient refusing to sign the informed consent form .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of a complication, linked to the rate of autoantibodies. | 2 years | The required complications are the followings: * endocarditis * thrombosis * thrombocytopenia * obstetrical complications: * Spontaneous miscarriage defined as a spontaneous expulsion of the embryo before 20 weeks gestation . * Spontaneous abortion * Fetal intrauterine death * Oligoamnios * Intrauterine growth retardation * Fetal malformations . |
Secondary
| Measure | Time frame |
|---|---|
| Rate of anti- cardiolipin antibodies | 1 day |
| Rate of anti- phagosome autoantibodies | 1 day |
Countries
France
Outcome results
None listed