Refractory Neoplasms
Conditions
Keywords
Effectivity, safety, irreversible electroporation, liver, pancreas
Brief summary
The pupose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for refractory neoplasms in liver and pancreas, the investigators used preoperative and postoperative US/CEUS/CT/MRI to assess lesions, and laboratory tests including the tumor markers to evaluate the general condition of patients. Intraoperative US/CEUS/CT would be applied to monitor ablation lesions.
Interventions
PROCEDUREElectroporation
Effectivity and safety of irreversible electroporation for refractory neoplasms in liver and pancreas
Sponsors
First Affiliated Hospital of Zhejiang University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with hepatic portal focal lesion adjacent to important structures like bile duct and portal blood vessels, or intolerant surgery. 2. Patients with pancreatic cancer adjacent to blood vessels, or intolerant surgery.
Exclusion criteria
Patients with: 1. Metal in the body 2. ChildPugh ≥ 3 3. Long-term use of anticoagulant drugs including warfarin, clopidogrel bisulfate 4. Poor cardiac or renal function with intolerant surgery or anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 60 patients of refractory neoplasms in liver and pancreas with irreversible electroporation-related effectivity as assessed by MRI | up to 24 months |
Countries
China
Contacts
Primary ContactTian'an Jiang, Phd
Backup ContactGuo Tian, Master
Outcome results
None listed