Breast Cancer, Colorectal Cancer, Kidney Cancer, Lung Cancer, Lymphoma, Ovarian Cancer, Prostate Cancer, Sarcoma
Conditions
Brief summary
The main objective of study is to describe the priorities of elderly patients (70 years and over) undergoing a first medical treatment for cancer, at initiation of treatment and after 3 months of treatment. The main criterion is a prioritization of 4 items per patient from a list of 8 expectations regarding the objectives of their treatment: treatment efficacy, life expectancy, autonomy, daily activities, social activities, heaviness of treatment, toxicity, economics.
Detailed description
For the primary endpoint assessment, this self-administered patient questionnaire will used an opinion scale (Not at all, A little, Moderately, Enough, Many) to explore the eight domains. Next to the completion of the expectations questionnaire, patients will have to order 4 of the different 8 items that they prioritized in regard of the first line treatment that has just been prescribed by their physician. Secondary endpoint will focus on those 8 proposed expectations of patients at different periods of time since treatment initiation. Patients' priorities will be compared to physician's priorities (using the same prioritization grid) before medical treatment and after 3 months of treatment and to younger patients' priorities (18-69 years). Associations between elderly patients' characteristics (social, medical…) and their priorities will be search.
Interventions
OTHERConsultation, evaluation questionnaire
Consultation, evaluation questionnaire
OTHERGeriatric consultation, evaluation questionnaire
Geriatric consultation, evaluation questionnaire
Sponsors
Fondation Université de Bordeaux
AG2R La Mondiale
Institut Bergonié
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male or female: 1. Age ≥ 70 years 2. Aged 18-69 years (case population) 2. ECOG / performance status 0-3 (WHO). 3. First line of medical oncology treatment (chemotherapy, targeted therapy, hormone therapy, combination): 1. Neo-adjuvant setting, 2. Adjuvant setting: previous neo-adjuvant treatment is allowed, 3. Metastatic setting: previous neo-adjuvant and/or adjuvant treatment are allowed, 4. Solid tumors (breast, colorectal, kidney, lung, prostate, sarcoma, and ovarian) and lymphoma (indolent and aggressive). 5. Life expectancy of more than 3 months. 6. Patients potentially compliant with the rules of the follow-up study. 7. Patients affiliated to a social security scheme. 8. Patients who received clear information from the investigator on the study and had not refused to participate.
Exclusion criteria
1. Exclusive surgery treatment. 2. Exclusive radiotherapy treatment or in combination with oncological medical treatment (concomitant radio-chemotherapy or radio-hormonotherapy). 3. Previous first line of oncological medical treatment in the same indication as the one concerned by the inclusion: 1. Neo-adjuvant setting: previous line(s) of neo-adjuvant medical treatment, 2. Adjuvant setting: previous line(s) of adjuvant medical treatment, 3. Metastatic setting: previous line(s) of metastatic medical treatment, 4. Supportive care without specific medical treatment 5. Previous or ongoing cancer under treatment at the time of inclusion. 6. Patient already included in this study 7. Patient who for psychological, psychiatric, social, family or geographical reasons could not be regularly monitored according to the criteria of the study; patient private of liberty or under guardianship.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Day 0 initiation of treatment | Prioritization among of the 4 items selected from a list of 8 expectations regarding the objectives of their treatment : treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden. For each expectation, the number and rate of priorization are reported. |
| Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | 3 months after initiation of treatment | Prioritization among of the 4 items selected from a list of 8 expectations regarding the objectives of their treatment : treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden. For each expectation, the number and rate of priorization are reported. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stability of Patients in Their Priorities at 3 Months | 3 months after initiation of treatment | For each expectation, stability is defined as the prioritization of the expectation at treatment initiation and 3 months after treatment initiation |
| Expectations of Patients at Initiation of Treatment | Day 0 initiation of treatment | Patients had to rate on a 5-point Likert scale (not at all / a little / moderately / quite / a lot) their expectations for treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden |
| Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Day 0 initiation of treatment | For each expectation, the agreement rate is defined by the same prioritization or non-prioritization by the patient-physician pairs. |
| 1-year Overall Survival | From inclusion to the end of study | Overall survival is defined as the time between the date of inclusion and the date of death, whatever the cause. The rate of overall survival is reported at 1 year |
| Expectations of Patients 3 Months After Initiation of Treatment | 3 months after initiation of treatment | Patients had to rate on a 5-point Likert scale (not at all / a little / moderately / quite / a lot) their expectations for treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden |
Countries
France
Participant flow
Recruitment details
Recruitment from January 2016 to January 2022 in 8 centers.
Pre-assignment details
Elderly patients (≥ 70 years of age) were recruited by the investigating oncologists or geriatricians at organ-specific multidisciplinary consultation meetings (RCP) or during consultations. Younger patients were identified and recruited in the same way, mainly through RCP or specialized consultation by oncologists.
Participants by arm
| Arm | Count |
|---|---|
| Elderly Patient (70 Years and Older) Geriatric consultation, evaluation questionnaire: Geriatric consultation, evaluation questionnaire | 227 |
| Young Patient (18 Years - 69 Years) Consultation, evaluation questionnaire: Consultation, evaluation questionnaire | 99 |
| Total | 326 |
Baseline characteristics
| Characteristic | Young Patient (18 Years - 69 Years) | Total | Elderly Patient (70 Years and Older) |
|---|---|---|---|
| Age, Continuous | 61.3 years | 75.9 years | 79.2 years |
| Race and Ethnicity Not Collected | — | 0 Participants | — |
| Region of Enrollment France | 99 participants | 326 participants | 227 participants |
| Sex: Female, Male Female | 71 Participants | 220 Participants | 149 Participants |
| Sex: Female, Male Male | 28 Participants | 106 Participants | 78 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 47 / 211 | 17 / 97 |
| other Total, other adverse events | 0 / 0 | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 | 0 / 0 |
Outcome results
Primary
Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment
Prioritization among of the 4 items selected from a list of 8 expectations regarding the objectives of their treatment : treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden. For each expectation, the number and rate of priorization are reported.
Time frame: 3 months after initiation of treatment
Population: Patients without major deviation on study protocol and eligibility criteria who indicated at least one priority in the prioritization grid 3 months after initiation of treatment
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Treatment efficacy | 145 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Life expectancy | 105 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Autonomy | 134 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Daily tasks | 93 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Social activities | 69 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Burden of treatment | 27 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Toxicity | 30 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Economic burden | 15 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Economic burden | 7 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Treatment efficacy | 85 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Social activities | 46 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Life expectancy | 72 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Toxicity | 22 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Autonomy | 66 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Burden of treatment | 8 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer 3 Months After Initiation of Treatment | Daily tasks | 44 Participants |
Primary
Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation
Prioritization among of the 4 items selected from a list of 8 expectations regarding the objectives of their treatment : treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden. For each expectation, the number and rate of priorization are reported.
Time frame: Day 0 initiation of treatment
Population: Patients without major deviation on study protocol and eligibility criteria who indicated at least one priority in the prioritization grid at the initiation of treatment
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Social activities | 80 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Autonomy | 181 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Burden of treatment | 47 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Life expectancy | 141 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Toxicity | 66 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Daily tasks | 115 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Economic burden | 13 Participants |
| Elderly Patient (70 Years and Older) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Treatment efficacy | 199 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Economic burden | 5 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Life expectancy | 80 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Autonomy | 67 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Daily tasks | 44 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Social activities | 47 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Burden of treatment | 17 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Toxicity | 35 Participants |
| Young Patient (18 Years - 69 Years) | Priorities of Patients Receiving First Medical Treatment for Cancer at Treatment Initiation | Treatment efficacy | 93 Participants |
Secondary
1-year Overall Survival
Overall survival is defined as the time between the date of inclusion and the date of death, whatever the cause. The rate of overall survival is reported at 1 year
Time frame: From inclusion to the end of study
Population: Patients without major deviation on study protocol and eligibility criteria who indicated at least one priority in the prioritization grid at the initiation of treatment
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Elderly Patient (70 Years and Older) | 1-year Overall Survival | 77.5 percentage of patient |
| Young Patient (18 Years - 69 Years) | 1-year Overall Survival | 85.2 percentage of patient |
Secondary
Agreement Rate for Prioritization of Expectations Between Patients and Physicians
For each expectation, the agreement rate is defined by the same prioritization or non-prioritization by the patient-physician pairs.
Time frame: Day 0 initiation of treatment
Population: Patients without major deviations from study protocol and eligibility criteria who indicated at least one priority in the prioritization grid at treatment initiation and whose physician also indicated at least one priority in the prioritization grid.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Social activities | 122 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Autonomy | 128 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Burden of treatment | 110 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Life expectancy | 123 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Toxicity | 91 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Daily tasks | 100 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Economic burden | 186 Participants |
| Elderly Patient (70 Years and Older) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Treatment efficacy | 174 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Economic burden | 93 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Life expectancy | 76 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Autonomy | 47 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Daily tasks | 45 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Social activities | 52 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Burden of treatment | 47 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Toxicity | 46 Participants |
| Young Patient (18 Years - 69 Years) | Agreement Rate for Prioritization of Expectations Between Patients and Physicians | Treatment efficacy | 84 Participants |
Secondary
Expectations of Patients 3 Months After Initiation of Treatment
Patients had to rate on a 5-point Likert scale (not at all / a little / moderately / quite / a lot) their expectations for treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden
Time frame: 3 months after initiation of treatment
Population: Patients without major deviation on study protocol and eligibility criteria who indicated at least one priority in the prioritization grid 3 months after initiation of treatment
| Arm | Measure | Group | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|---|
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Not at all | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | A little | 5 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Moderately | 9 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Quite | 23 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | A lot | 115 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Not at all | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | A little | 9 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Moderately | 18 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Quite | 31 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | A lot | 91 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Not at all | 1 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | A little | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Moderately | 5 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Quite | 18 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | A lot | 126 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Not at all | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | A little | 11 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Moderately | 17 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Quite | 38 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | A lot | 87 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Missing | 0 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Not at all | 9 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | A little | 14 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Moderately | 20 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Quite | 34 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | A lot | 76 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Not at all | 16 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | A little | 13 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Moderately | 23 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Quite | 41 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | A lot | 62 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Missing | 0 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Not at all | 14 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | A little | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Moderately | 14 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Quite | 43 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | A lot | 80 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Missing | 0 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Not at all | 31 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | A little | 15 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Moderately | 10 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Quite | 30 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | A lot | 67 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Missing | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Not at all | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Not at all | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | A little | 4 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | A little | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Moderately | 5 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | A little | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Quite | 10 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Moderately | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | A lot | 68 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | A little | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Treatment efficacy | Missing | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Quite | 22 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Not at all | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Moderately | 8 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | A little | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | A lot | 61 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Moderately | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | A lot | 31 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Quite | 14 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Social activities | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | A lot | 70 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Quite | 25 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Life expectancy | Missing | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Not at all | 7 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Not at all | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Moderately | 11 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | A little | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | A little | 4 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Moderately | 3 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | A lot | 51 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Quite | 19 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Moderately | 13 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | A lot | 65 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | A little | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Autonomy | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Quite | 26 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Not at all | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | A lot | 38 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Moderately | 4 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Quite | 23 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Quite | 23 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Burden of treatment | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | A lot | 58 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Economic burden | Not at all | 22 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Daily tasks | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients 3 Months After Initiation of Treatment | Toxicity | Not at all | 2 Participants |
Secondary
Expectations of Patients at Initiation of Treatment
Patients had to rate on a 5-point Likert scale (not at all / a little / moderately / quite / a lot) their expectations for treatment efficacy, life expectancy, autonomy, daily tasks, social activities, burden of treatment, toxicity and economic burden
Time frame: Day 0 initiation of treatment
Population: Patients without major deviation on study protocol and eligibility criteria who indicated at least one priority in the prioritization grid at the initiation of treatment
| Arm | Measure | Group | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|---|
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Economic burden | Quite | 35 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Burden of treatment | A lot | 124 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Missing | 1 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Toxicity | Not at all | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Toxicity | A little | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Toxicity | Moderately | 17 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Toxicity | Quite | 40 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Toxicity | A lot | 144 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Toxicity | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Economic burden | Not at all | 28 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Economic burden | A little | 15 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Economic burden | Moderately | 34 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Quite | 49 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Economic burden | A lot | 92 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Economic burden | Missing | 7 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Not at all | 3 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | A little | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Moderately | 5 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Quite | 24 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | A lot | 173 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Life expectancy | Not at all | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Life expectancy | A little | 5 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Life expectancy | Moderately | 23 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Life expectancy | Quite | 38 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Life expectancy | A lot | 139 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Daily tasks | Not at all | 4 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Life expectancy | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Autonomy | Not at all | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Autonomy | A little | 0 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Autonomy | Moderately | 7 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Autonomy | Quite | 23 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Autonomy | A lot | 178 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Autonomy | Missing | 1 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Daily tasks | A little | 9 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Daily tasks | Moderately | 23 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Daily tasks | Quite | 37 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Daily tasks | A lot | 136 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Daily tasks | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Social activities | Not at all | 5 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Social activities | A little | 12 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Social activities | Moderately | 21 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Social activities | Quite | 36 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Social activities | A lot | 135 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Social activities | Missing | 2 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Not at all | 6 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Burden of treatment | A little | 6 Participants |
| Elderly Patient (70 Years and Older) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Moderately | 25 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Burden of treatment | A little | 4 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Quite | 24 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Life expectancy | Quite | 8 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Burden of treatment | A lot | 55 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Daily tasks | Quite | 19 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Social activities | Quite | 19 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Toxicity | Not at all | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Life expectancy | A lot | 85 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Toxicity | A little | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Daily tasks | A lot | 74 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Toxicity | Moderately | 8 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Life expectancy | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Toxicity | Quite | 16 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Not at all | 6 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Toxicity | A lot | 71 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Autonomy | Not at all | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Toxicity | Missing | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Daily tasks | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Economic burden | Not at all | 17 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Autonomy | A little | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Economic burden | A little | 6 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Social activities | A lot | 74 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Economic burden | Moderately | 13 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Autonomy | Moderately | 3 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Economic burden | Quite | 16 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Social activities | Not at all | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Economic burden | A lot | 45 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Autonomy | Quite | 16 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Economic burden | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Burden of treatment | Moderately | 8 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Not at all | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Autonomy | A lot | 75 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | A little | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Social activities | A little | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Moderately | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Autonomy | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Quite | 4 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Daily tasks | Not at all | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | A lot | 91 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Social activities | Missing | 0 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Treatment efficacy | Missing | 2 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Daily tasks | A little | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Life expectancy | Not at all | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Social activities | Moderately | 4 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Life expectancy | A little | 1 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Daily tasks | Moderately | 3 Participants |
| Young Patient (18 Years - 69 Years) | Expectations of Patients at Initiation of Treatment | Life expectancy | Moderately | 2 Participants |
Secondary
Stability of Patients in Their Priorities at 3 Months
For each expectation, stability is defined as the prioritization of the expectation at treatment initiation and 3 months after treatment initiation
Time frame: 3 months after initiation of treatment
Population: Patients without major deviation on study protocol and eligibility criteria who indicated at least one priority in the prioritization grid at the initiation of treatment and 3 months after treatment initiation
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Treatment efficacy | 137 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Life expectancy | 74 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Autonomy | 119 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Daily tasks | 59 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Social activities | 35 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Burden of treatment | 8 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Toxicity | 11 Participants |
| Elderly Patient (70 Years and Older) | Stability of Patients in Their Priorities at 3 Months | Economic burden | 2 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Economic burden | 1 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Treatment efficacy | 82 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Social activities | 25 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Life expectancy | 62 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Toxicity | 15 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Autonomy | 51 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Burden of treatment | 1 Participants |
| Young Patient (18 Years - 69 Years) | Stability of Patients in Their Priorities at 3 Months | Daily tasks | 24 Participants |