Peanut Allergy
Conditions
Brief summary
This project intends the analysis and profiling of specific antibodies against major peanut allergens in peanut allergic individuals and molecular cloning of human antibodies against major peanut allergens.
Detailed description
* Characterization of patient samples reactivity (sera obtained from blood) against major peanut allergens. * Isolation of antibody-producing B cells. * Molecular cloning of peanut-specific antibodies from antibody gene sequences obtained from B cells. * Biophysical and functional characterization of isolated antibodies
Interventions
OTHERObservational study
Blood sampling
Sponsors
University Children's Hospital, Zurich
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants have a described clinical history of peanut allergy and/or are sensitized to peanut allergens (as evidenced by positive skin prick test and allergen-specific IgE testing) * Male and female subjects older than 3 years * Written informed consent
Exclusion criteria
* age below three years * patients suffering from any disease where blood withdrawals might impact the patients' health status such as known anemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis and profiling of specific antibodies against major peanut allergens in samples derived from peanut allergic patients. | June 2016 to May 2018 |
Outcome results
None listed