Modified INSURE Technique
Conditions
Brief summary
In preterm infants with respiratory distress syndrome, mechanical ventilation is related to increased risk of death and complications. Surfactant is an important methods to reduce mortality and intubation rates. INSURE technique is a standard method to administrate surfactant. However, several preterm infants need two or more surfactant, and therefore one more intubation is needed. How to reduce the times of intubation is an challenges for neonatologists.
Detailed description
INSURE technique meas surfactant administration through intubation-surfactant-extubation. And noninvasive ventilation is immediately used after surfactant. The differences of modified INSURE compared with INSURE is intubation-surfactant-X-ray relieved-extubation. Extubation and noninvasive ventilation is used after the X-ray relieving.
Interventions
OTHERModified INSURE technique
modified INSURE means intubation-surfactant-X-ray relieved-extubation. Extubation and noninvasive ventilation is used after the X-ray relieving.
OTHERINSURE technique
INSURE means intubation-surfactant-extubation. Extubation and noninvasive ventilation is used after surfactant administration.
Sponsors
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Hours
Healthy volunteers
No
Inclusion criteria
* All preterm infants with respiratory distress syndrome
Exclusion criteria
* congenital abnormalities or refuse the trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intubation rate | 100-days |
Countries
China
Contacts
Primary ContactWu Fang, MD
Outcome results
None listed