Retinopathy of Prematurity
Conditions
Brief summary
The development of the retinal vascular network is generally complete during the 3rd trimester of pregnancy but may continue during the first 15 days of life. This late maturation may cause problems in pre-term births and may result in immature vascularization of the retina, a condition called retinopathy of prematurity. Among the different factors affecting the development of the retinal vasculature, the tissue level of omega-3 polyunsaturated fatty acids (PUFA) appears to be a crucial element, as does the form of the PUFA present in the tissues (nature of the phospholipids in their membranes). This project aims to show a possible association between levels of omega-3 PUFA and the onset of retinopathy of prematurity (ROP).
Interventions
OTHERRETCAM
BIOLOGICALBlood samples
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Months to 4 Months
Healthy volunteers
No
Inclusion criteria
* Premature new-born infants born at less than 29 weeks of amenorrhea after informed consent has been obtained from a parent or the legal guardian of the infant
Exclusion criteria
* Premature new-born infants presenting a life-threatening condition. Persons without national health insurance cover
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stage of retinopathy of prematurity using a Retcam according to the ICROP classification (International Classification of Retinopathy of Prematurity) revised in 2005. | At 4 weeks of life or 31 weeks of amenorrhea |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations of omega-3 PUFA in Red Blood Cell (RBC) membranes. | At inclusion |
Countries
France
Outcome results
None listed