Hypertension
Conditions
Keywords
hypertension, early onset, target organ damage
Brief summary
Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.
Detailed description
In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.
Interventions
None listed
Sponsors
China National Center for Cardiovascular Diseases
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| primary mortality of early-onset hypertension | through study completion, an average of 5 years | the primary mortality of early-onset hypertension |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| secondary outcomes of heart | through study completion, an average of 5 years | The incidence rate of left ventricular hypertrophy, myocardial infarction, congestive heart failure, and arrhythmia. |
| secondary outcomes of brain | through study completion, an average of 5 years | The incidence rate of stroke (include cerebral hemorrhage and cerebral ischemia) |
| secondary outcomes of kidney | through study completion, an average of 5 years | The incidence rate of hypertensive renal injure and end-stage renal disease |
| secondary outcomes of eyes | through study completion, an average of 5 years | The incidence rate of hypertensive eye injure |
Countries
China
Contacts
Primary ContactLei Song, MD.& PhD.
Backup ContactLei Song, MD.& PhD.
Outcome results
None listed