Brain Ischemia
Conditions
Keywords
ischemic stroke, brain reserve, cognitive reserve, cognitive prognosis
Brief summary
Ischemic strokes are one of the leading causes of handicap and death in elderly people in France. Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status… Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology. Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases. The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.
Interventions
OTHERneurologic and neuropsychological evaluation
cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥70 years old * right middle cerebral artery ischemic stroke * hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016
Exclusion criteria
* Contraindication for MRI * Hemorrhagic stroke * Aphasia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| evaluation of cognitive prognosis | one year post Ischemic stroke | measure will be performed with the Mattis dementia rating scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Volume of leucoencephalopathy | one year post Ischemic stroke | measure will be performed with a MRI |
| volume of hippocampic | one year post Ischemic stroke | measure will be performed with a MRI |
| brain injury | one year post Ischemic stroke | measure will be performed with a MRI |
| volume of ischemic stroke | one year post Ischemic stroke | measure will be performed with a MRI |
| evaluation of cognitive reserve | one year post Ischemic stroke | measure will be performed with the Cognitive reserve index questionnaire |
Countries
France
Outcome results
None listed