Association Between Brain Stimulations for the Rehabilitation of Chronic Stroke Patients

Association Between Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation for Chronic Stroke Patients Rehabilitation: a Randomized Clinical Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02817867

Enrollment

Registered

2016-06-29

Start date

2016-06-30

Completion date

2017-12-31

Last updated

2019-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Brief summary

Cerebrovascular accident (CVA) is a cerebrovascular disease with high incidence and morbidity in the Brazilian population, and is considered a major cause of disability in adults. Brain damage caused by stroke generates a maladaptive pattern of neural activity and modulation between the cerebral hemispheres, unbalancing in the inter-hemispheric inhibition. This condition affects patient's functional recovery. The aim of this study is to verify the effectiveness of repetitive transcranial magnetic stimulation Association (rTMS) in the cortex motor contralesional, Transcranial Direct Current Stimulation (tDCS) in the motor cortex ipsilesional and the association between these two types of brain stimulations on the upper limb recovery after stroke.

Interventions

DEVICEtDCS

Transcranial direct current stimulation (tDCS)

DEVICETMS

Transcranial magnetic stimulation

DEVICEtDCS + TMS

Association between tDCS and TMS.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Subcortical stroke diagnosis, which has resulted in hemiparesis for at least 6 months and not more than 5 years (chronic condition); * Ability to reach 60 degrees in the shoulder flexion * Ability to completely extend the fingers in the affected upper limb; * Minimal cognitive ability to understand commands; * No current use of antiepileptic drugs for seizures.

Exclusion criteria

* Painful shoulder, adhesive capsulitis or glenohumeral subluxation; * Contraindication (presence of metallic implants) or risks for the Transcranial magnetic stimulation, as evaluated by means of a standard questionnaire;

Design outcomes

Primary

Measure	Time frame
Motor Function by means of the Wolf Motor Function Test	change from pre to post (at least 10 days)

Secondary

Measure	Time frame
Grip strength via hand dynamometer	change from pre to post (at least 10 days)
Manual Dexterity by means of the Box and Block Test	change from pre to post (at least 10 days)
Quality of Life by means of the Stroke Impact Scale	change from pre to post (at least 10 days)

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026