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NEWS and Rapid Lactate Testing for Early Identification of High Risk Patients in the Emergency Department

Validation of National Early Warning Score (NEWS) and Rapid Lactate Testing for Early Identification of High Risk Patients in the Emergency Department

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02817581
Enrollment
1255
Registered
2016-06-29
Start date
2016-07-31
Completion date
2017-12-30
Last updated
2018-08-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Triage Category 3 (Urgent)

Keywords

National Early Warning Score (NEWS), Lactate, Emergency Department

Brief summary

To validate the NEWS and rapid lactate testing for early identification of high risk \[triage Category 3 (urgent)\] patients in the Emergency Department. To compare qSOFA and SIRS criteria in patients in the Emergency Department.

Detailed description

Background: Sepsis is a potentially life-threatening complication of an infection. Early identification and early intervention are two main elements in improving patient care. Objectives: 1. To validate the NEWS and rapid lactate testing for early identification of high risk \[triage Category 3 (urgent)\] patients in the Emergency Department. 2. To compare qSOFA and SIRS criteria in patients in the Emergency Department. Study design: This is a prospective, cohort study. Patients aged 18 or above presenting to the ED triaged as Category 3 (urgent) will be recruited. The required data for calculating NEWS will be collected at triage and triage lactate level will be measured by point-of-care analyzer. Outcomes: The primary outcome is referral for intensive care unit (ICU) admission during the patient's ED stay. The secondary outcomes are length of stay in hospital (LOS), hospital admission, admission to ICU, length of ICU-free admission (defined as days alive outside the ICU from admission to day 30) 30-day mortality and time to processes-of-care.

Interventions

None listed

Sponsors

Chinese University of Hong Kong
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Aged 18 years or above who are triage category 3 in emergency department * Presenting to emergency department between 9am and 4pm, Monday to Friday

Exclusion criteria

* Aged below 18 years * Pregnant

Design outcomes

Primary

MeasureTime frame
30-day mortality30 days after recruitment

Secondary

MeasureTime frameDescription
length of stay in hospital (LOS)30 days after recruitment
hospital admission30 days after recruitment
referral for intensive care unit (ICU) admission24 hr after recruitment
length of ICU-free admission30 days after recruitment
time to processes-of-care24 hr after recruitmenttime to lactate measured, time to antibiotics admission, time to blood culture obtained, time to fluid resuscitation, time to vasopressor administration from ED arrival
admission to ICU30 days after recruitment

Countries

Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026