Study of Postoperative Delirium in Elderly People After Orthopedic Surgery

microRNA and Delirium After Hip and Knee Fracture

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02817386

Enrollment

Registered

2016-06-29

Start date

2015-03-31

Completion date

2016-02-29

Last updated

2017-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Delirium

Keywords

postoperative delirium, microRNA

Brief summary

The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.

Detailed description

Postoperative delirium is one of the most common postoperative complications in elderly patients.It has been shown that postoperative delirium has independent adverse effects on short and long-term mortality and morbidity, including poor functional recovery, postoperative cognitive dysfunction, deterioration in quality of life, and increased costs. However, at the present time, postoperative delirium is a clinical phenomenon, and its neuropathogenesis remains unknown. This gap in knowledge has become a barrier that limits further studies, including the development of potential interventions for postoperative delirium.

Interventions

OTHERinterview

Trained clinical research assistants interviewed the patients on the first and second day post surgery. The interview included the Confusion Assessment Method (CAM) and MDAS. CAM is a diagnostic algorithm used to determine the presence or absence of delirium.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. 65 years old or older 2. candidates for spinal anesthesia 3. Non language communication barriers

Exclusion criteria

1. past medical history of neurological and psychiatric diseases including AD, other forms of dementia, stroke, or psychosis; 2. severe visual or hearing impairment; 3. unwillingness to comply with the protocol or procedures.

Design outcomes

Primary

Measure	Time frame	Description
The level of microRNA in cerebrospinal fluid and serum	through study completion, an average of 1 year	All of the participants had spinal anesthesia for the scheduled surgery. Two milliliter of CSF was collected from a spinal needle by anesthesiologists during the spinal anesthesia before the administration of the local anesthetic. Blood samples were collected from patients prior to spinal anesthesia.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026