Analgesia, Hepatectomy, Nerve Block
Conditions
Brief summary
This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection TPVB +continuous(pulsatile infusion) TPVB and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
Interventions
PROCEDUREsingle-injection TPVB + continuous TPVB
Inject local anesthetics in the T8 paravertebral space followed with catheter insertion and continuous local infusion.
The curved (C1-5) probe of Philip CX 50 Ultrasound Scanner is used for scanning
* 2mg/kg ropivacaine in saline with 1:200,000 adrenaline, 25ml in total * given immediately after the correct position of the tip of the needle has been confirmed
DRUGcontinuously infusion of ropivacaine
* 0.2% ropivacaine, pulse dosadge: 0.125ml/kg/pulse, 1pulse/h at a rate of 6ml/minutes * given through the catheter inserted in the T8 paravertebral space following the single dose
bolus: 2mg, lock time: 10min, 1h limitation: 8mg
Sponsors
Cui Xulei
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo hepatectomy with J-shape subcostal incision * Informed consent
Exclusion criteria
* A known allergy to the drugs being used * Coagulopathy, on anticoagulants * Analgesics intake, history of substance abuse * Participating in the investigation of another experimental agent * Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cumulative morphine consumption | within 48 postoperative hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| nausea and vomiting score | At 0, 2,4, 8, 12, 24 and 48hours after the surgery | — |
| pruritus score | At 0, 2,4, 8, 12, 24 and 48hours after the surgery | — |
| ambulation time | within the 7 days after surgery | — |
| The pain scores determined by the numeric rating scale (NRS, 0-10) | At 0, 2,4, 8, 12, 24 ,48,72hours and 7day after the surgery | — |
| Postoperative hospital length of stay | Up to 4 weeks | — |
| patient satisfaction with anesthesia | 48 hours after surgery | use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia |
| data collection of chronic pain | at 3,6,12 months after surgery | Patients undergo a telephone interview with a questionnaire at 3, 6 and 12 months after surgery, the incidence and severity of chronic pain is recorded. |
| time of recovery of bowl movement | within the 7 days after surgery | — |
Countries
China
Outcome results
None listed