Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL

Effects of Holy-Comod and Tears Naturale Forte on Ocular Surface and Tear Inflammatory Mediators in Patients After Phaco+IOL

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02817191

Enrollment

Registered

2016-06-29

Start date

2016-06-30

Completion date

2016-11-30

Last updated

2016-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-related Cataract

Keywords

age-related cataract, Holy-Comod, Tears Naturale Forte, phacoemulsification, inflammatory mediators

Brief summary

The purpose of the study it to compare the effects of Holy-Comod and Tears Naturale Forte on ocular surface and tear inflammatory mediators in patients after Phaco+IOL.

Interventions

DRUGHylo-Comod eye drop

The patients were administrated Hylo-Comod eye drop four times a day after Phaco+IOL

DRUGTears Naturale Forte eye drop

The patients were administrated Tears Naturale Forte eye drop four times a day after Phaco+IOL

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

60 Years to 72 Years

Healthy volunteers

Yes

Inclusion criteria

* 60-72 years old * classification of lens nucleus is LOCS Ⅱ

Exclusion criteria

* patients with previous history of ocular surgery, corneal diseases,uveitis ,ocular hypertension or glaucoma ,systemic diseases.

Design outcomes

Primary

Measure	Time frame
concentration of matrix metalloproteinase-9	up to 2 months after surgery
scale of Schirmer I test	up to 2 months after surgery
scale of corneal fluorescein staining	up to 2 months after surgery
scale of noninvasive tear breakup time	up to 2 months after surgery
questionnaire of ocular surface disease index	up to 2 months after surgery
scale of central corneal sensitivity	up to 2 months after surgery
scale of tear meniscus height	up to 2 months after surgery
concentration of Interleukin-1α	up to 2 months after surgery
concentration of tumor necrosis factor-α	up to 2 months after surgery
concentration of nerve growth factor	up to 2 months after surgery
concentration of interferon-γ	up to 2 months after surgery
concentration of transforming growth factor-β1	up to 2 months after surgery

Secondary

Measure	Time frame
Correlation Between Inflammatory Mediators and Ocular Surface Changes	up to 2 months after surgery

Countries

China

Contacts

Primary ContactCHI ZHANG, MD, PhD

mike0946@163.com+8613790077756

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026