Low-level Laser Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabetics

Low-level Laser Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabetics: Split-mouth Double-blind Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02817152

Enrollment

Registered

2016-06-29

Start date

2014-02-28

Completion date

2015-09-30

Last updated

2016-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis, Diabetes Mellitus

Keywords

periodontal treatment, low-level light therapy

Brief summary

The aim of this study was to investigate the local effect of adjunct low-level laser therapy (LLLT) for the treatment of moderate to severe chronic periodontitis in type 2 diabetic patients.

Detailed description

The aim of this study was to investigate the local effect of adjunct low-level laser therapy (LLLT) for the treatment of moderate to severe chronic periodontitis in type 2 diabetic patients. Twenty poorly-controlled type 2 diabetic patients with moderate to severe generalized chronic periodontitis were selected. Two periodontal pockets with Probing Depth (PD) and Clinical Attachment Level (CAL) ≥ 5mm received ultrasonic periodontal debridement (UPD) only (control group) or UPD with LLLT (test group). Clinical measures, such as PD, CAL, Gingival Recession (GR), Bleeding on Probing (BoP), and Plaque Index (PI), were collected and compared at baseline, 30, 90, and 180 days. The adjunct application of LLLT to UPD had no additional benefits for PD reduction and CAL gain, meaning that both investigated therapies were efficient for the treatment of chronic periodontitis in type 2 diabetics. Nevertheless, additional LLLT application showed better results for GR then UPD only.

Interventions

PROCEDUREPeriodontal ultrasonic debridement

Periodontal pockets received periodontal ultrasonic debridement intervention.

DEVICEDebridement plus low-level laser therapy

Ultrasonic debridement plus low-level laser therapy.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

35 Years to 75 Years

Healthy volunteers

Inclusion criteria

* age ≥ 35; diagnosis of type 2 diabetes for ≥ 5 years; diabetes treatment with oral hypoglycemic agents or insulin supplementation and diet; glycated hemoglobin (HbA1c) levels from 6.5% to 11%; at least 15 teeth (excluding third molars and teeth indicated for extraction); and moderate to severe generalized chronic periodontitis.

Exclusion criteria

* The

Design outcomes

Primary

Measure	Time frame
Probing depth change from baseline to 30, 90, and 180 days through periodontal probing	baseline, 30 days, 90 days, 180 days

Secondary

Measure	Time frame
Clinical attachment level change from baseline to 30, 90, and 180 days through periodontal probing	baseline, 30 days, 90 days, 180 days
Gingival recession change from baseline to 30, 90, and 180 days through periodontal probing	baseline, 30 days, 90 days, 180 days
Bleeding on probing change from baseline to 30, 90, and 180 days through periodontal probing	baseline, 30 days, 90 days, 180 days
Plaque index change from baseline to 30, 90, and 180 days through periodontal probing	baseline, 30 days, 90 days, 180 days

Other

Measure	Time frame
Glycated hemoglobin	Baseline, 180 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026