Healthy Volunteers
Conditions
Keywords
functional Magnetic Resonance Imaging, Galvanic Vestibular Stimulation, Feedback Processing, Reward, Social, Vestibular System, Cingulate Cortex, Decision-making
Brief summary
The purpose of this research is to identify and probe the neural networks involved in feedback processing. It aims at translating this knowledge to clinical populations in which this network is disrupted or compromised. It includes two studies: 1) with fMRI in healthy subjects to identify the neural bases of feedback processing on decision making using different types of feedback (neutral, social and monetary) presented either infra- or supra-laminary and 2) probing the role of one structure, the anterior cingulate cortex, using Galvanic Vestibular Stimulation (GVS) in healthy subjects. The interventional part consists in the administration of Galvanic Vestibular Stimulation (GVS), which by means of small intensity currents activates the vestibular organs and subsequently vestibular-related brain areas. GVS will be delivered to healthy participants engaged in behavioural tasks requiring the processing of feedbacks of different nature (e.g. social or monetary feedbacks)
Interventions
OTHERmRI
Neural bases of feedbacks' influence on decision making processes
OTHEREffect of Galvanic Vestibular Stimulation on decision making processes
Galvanic Vestibular Stimulation (GVS) stimulates the vestibular system through low intensity electric currents applied at the basis of the VIII cranial nerve, upon the mastoid processes. In the Right-Anodal condition the positive electric charge is applied through electrodes placed upon the right mastoid and it mainly activates structures within the left brain hemisphere. In the Left-Anodal condition the positive electric charge is applied through electrodes placed upon the left mastoid and it mainly activates structures within the right brain hemisphere. In the SHAM condition, low intensity electric currents are applied 5 cm below the mastoid processes. This condition does not activate the vestibular system and serves as a control condition to account for unspecific activating effects of all electric stimulations (e.g., arousal, discomfort). The three conditions will be applied in three different sessions (i.e. days) in randomized order.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Benefit of social health security * Normal or corrected-to-normal vision
Exclusion criteria
* Anamnesis of neurological of psychiatric illness * Pregnancy or breastfeeding * Administrative measures restricting legal rights * Epilepsy (including familiarity), migraines, chronic headaches * presence of pacemakers, cochlear implants, surgical clips, or any metallic component fixed in participants' body * Current treatment with psychotropic drugs * Alcohol assumption during the last 24 hours * Sleep deprivation * Recent participation to other brain stimulation studies (\< 1 week)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Behavioral performance (Accuracy) | up to 4 days | The proportion of correct responses, automatically computed by professional programs (e.g. Presentation) running on standard Personal Computers depending on different contexts (e.g. different feedback: neutral, social and monetary). |
| Behavioral performance (Reaction times) | up to 4 days | The proportion of reaction times provided, automatically computed by professional programs (e.g. Presentation) running on standard Personal Computers depending on different contexts (e.g. different feedback: neutral, social and monetary). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neural activity (BOLD signal measured using fMRI) as a function of the nature of the feedback. | up to 4 days | Neural activity changes during learning of visuomotor associations in different contexts (e.g. different feedback: neutral, social and monetary) measured using Blood-oxygen-level dependent contrast imaging (BOLD). |
Countries
France
Outcome results
None listed