Heart Arrest
Conditions
Keywords
PV-loops (pressure-volume loops), Myocardial contractility, Cardioplegia, Induced
Brief summary
Myocardial protection is a fundamental element for the safety of patients when performing cardiac surgery. For this purpose, cardioplegia were rapidly established in clinical practice to protect the myocardium when performing aortic clamp. Cardioplegia are procedures to stop the contraction of myocardium. It is usually achieved with the use of chemicals ( cardioplegic solutions) or cold temperature (such as chilled perfusate). The composition of the cardioplegic solutions and their method of administration continuously changed over the years. At the present date, cold blood cardioplegias are performed in the investigator's center. The investigators regularly use two modes of administration: either by an antegrade path (injection in the coronary arteries), or a retrograde one (injection in the venous system). At present, there are no elements supporting the superiority or inferiority of one path compared to another. The difficulty lies within a clear estimation of the contractility state of the ventricular cardiac muscle. Technological developments in recent years provided a solution to this problem. The analysis of the pressure/volume curves generated by a ventricle allows an accurate quantification of the myocardial contractility. This requires the use of conductance catheters to accurately measure the ventricular volume and the ventricular pressure. The absolute ventricular contractility is then deduced with the help of a software. The investigators intend to use this pressure-volume loops, obtained with conductance catheters, to compare the contractility of the right heart ventricle after antegrade vs retrograde cardioplegia.
Interventions
PROCEDUREAntegrade cardioplegia
Injection of the cardioplegia in the coronary arteries
PROCEDURERetrograde cardioplegia
Injection of the cardioplegia in the venous system
Sponsors
Brugmann University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Need for myocardial revascularisation * Normal FEVG ( \> 50%)
Exclusion criteria
* Valvulopathy * Associated procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contractility index of the right ventricle | Baseline | Cardiac surgery is performed according to the standard of care. The intraventricular pressure and the ventricular volume, measured with a conductance catheter, are combined within a software to compute the contractility index of the right ventricle. The baseline measure will be performed before the instauration of the extracorporeal blood circulation, during the cardiac surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Troponin post operative level | 6h post surgery | The investigators would like to measure post operative troponin levels as a biological marker of myocardial protection |
Countries
Belgium
Outcome results
None listed