Etiology of Endocarditis in Negative Blood Cultures

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02816307

Acronym

ENDOC

Enrollment

3033

Registered

2016-06-28

Start date

2013-06-07

Completion date

2022-10-26

Last updated

2023-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infective Endocarditis (IE)

Brief summary

Infective endocarditis remains a serious disease that requires fast and specialized support in 2012. However, 24% of endocarditis unanswered etiology. The systematic use of new policy diagnosis, including (i) a systematic use of specific PCR techniques and (ii) the search for markers of inflammatory and tumoral diseases, should increase the number of positive etiological diagnosis of culture-negative samples. Secondly, because of the seriousness of the disease, the investigators were led to develop a new score: score for admission. This score, realized in less than 4 hours from the admission of the suspected patient with endocarditis, should allow for immediate probabilistic antibiotic treatment after completion of the diagnostic kit. The modified Duke score give its results in 4 to 7 days. With the score of admission thus diagnostic processes are accelerated and, where appropriate, empirical antibiotic therapy started. Primary: Evaluate the effectiveness of the new diagnostic strategy on etiological identification of endocarditis. Secondary: Validate the admission score compared to the modified Duke score.

Interventions

OTHERblood samples

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient with endocarditis diagnostic kit prescribed * Patient is more than 18 years old * Patient who freely signed written informed consent. * Patient affiliated to a health assurance

Exclusion criteria

* Minor patient (\<18 years) * Patient pregnant or breastfeeding * Patient incapable or unable to consent * Private patient of liberty or under court order * Patient refusing to participate in the research

Design outcomes

Primary

Measure	Time frame
The percentage of patients with an etiological diagnosis of endocarditis	6 years

Secondary

Measure	Time frame
The admission score	1 day
the Duke score	1day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026