diabète de Type 1
Conditions
Brief summary
In type-1 diabetes patients, bad cholesterol tends to accumulate because apoC1 function is slowed down. ApoC1 is a protein whose role is to diminish the activity of CETP, another protein that regulates cholesterol transfer in the body. The aim of this study is to determine whether it is possible to correct apoC1 function by improving glycaemic balance. 240 persons will be recruited in this study and allocated to one of two groups: * 160 Type-1 diabetes patients with uncontrolled diabetes: * 4 additional blood samples will be taken at the time of the systematic biological examination at inclusion and then again 3 months later. * 80 control subjects with normal lipids and normal glycaemia balance will be included in the study following the results of the biological assays. * 4 blood samples will be taken at the time of inclusion.
Interventions
BIOLOGICALPrise de sang
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for patients: * Patients over 18 years * Patients with type-1 diabetes and glycated hemoglobin (HbA1C) \>9% Inclusion criteria controls: * Subjects over 18 years * Normal glycaemia (Fasting glycaemia \<1.10 g/L) and normal lipids (Low-density lipoproteins (LDL) \<1.6 g/L, triglycerides (TG) \<1.5 g/L)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparaison of linear correlation coefficients between plasma concentrations of apoC1 and CETP activity | 3 mois |
Countries
France
Outcome results
None listed