Cerebellar Alterations in Individuals With a Cannabis Use Disorder

Alterations in Cerebellar-dependent Adaptation Due to Cannabis Use Measured With an Explicit-implicit Visuo-motor Learning Paradigm

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02816034

Enrollment

Registered

2016-06-28

Start date

2016-06-30

Completion date

2017-04-30

Last updated

2018-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cannabis

Keywords

Learning, Cerebellum

Brief summary

The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

Interventions

BEHAVIORALVisuo-motor rotation

Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.

BEHAVIORALExplicit strategy

Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria. * Patients screen positive to cannabis in the urine analysis performed a week prior to assessment. * Right-handed patients. * Patients provide a signed consent.

Exclusion criteria

* Patients with another current substance use disorder (with the exception of tobacco). * Patients with a visual impairment that has not been corrected. * Patients with a cognitive impairment such as mental retardation. * Patients with psychotic disorders.

Design outcomes

Primary

Measure	Time frame
Directional error of hand trajectories towards a target	1 day (a single session)

Secondary

Measure	Time frame
Reaction times	1 day (a single session)
Intrinsic Motivational Inventory	1 day (a single session)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026