Cognition Disorders, Cognitive Deficits
Conditions
Keywords
cognitive rehabilitation, memory, attention, spatial neglect, executive dysfunctioning
Brief summary
Cognitive rehabilitation is defined as a systematic functionally oriented intervention of therapeutic cognitive activities based on the assessment and understanding of patient's brain behavior deficits. This project focuses on restoring cognitive functions in order to understand the underlying deficits in the patient's brain by developing integrated cognitive rehabilitation scenarios in virtual reality that combine memory, attention and problem solving training with context specific motor movements.
Interventions
BEHAVIORALCognitive rehabilitation training with RGS in the clinic
Daily cognitive training with the Rehabilitation Gaming System (RGS) in the clinic during 6 weeks (5 days per week a 30 minutes).
BEHAVIORALPassive/conventional cognitive training at home.
Daily conventional cognitive rehabilitation at home as recommended by the neurologist during 6 weeks (5 days per week a 30 minutes).
Sponsors
Hospital de la Esperanza
Universitat Pompeu Fabra
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Score on Mini-Mental State Examination between 18 - 24 * Score on Montreal Cognitive Assessment less than 26 * More than 2 points in upper limb motor scale MRC * Sufficient cognitive ability to understand and follow the experimental instructions
Exclusion criteria
* Score on Mini-Mental State Examination below 18 or above 24 * Score on Montreal Cognitive Assessment of 26 or above * Below 2 point in upper limb motor scale MRC * Hemianopia * Cognitive capacity that prohibits the execution of the experiment * Severe impairment like spasticity, aphasia or apraxia, major pain or other neuromuscular impairments or dependent on use of orthopedic devices that would interfere with the correct execution of understanding of the experiment * History of serious mental-health problems in acute or subacute phase * Patients that do not give their consent to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Star Cancellation test from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of spatial neglect |
| Change in Corsi block-tapping test reversed from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of working memory |
| Change in Frontal Assessment Battery from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of executive functioning |
| Change in Trail Making Test, Part B from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of set-shifting |
| Change in Digit Symbol Coding in WAIS-IV from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of processing speed |
| Change in Digit Span Forward WAIS-IV from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of attention |
| Change in Corsi block tapping test from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of attention |
| Change in Trail Making Test, Part A from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of attention |
| Change in Rey Auditory Verbal Learning Test from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of episodic memory |
| Change in Digit Span Backward WAIS-IV from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of working memory |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Mini-Mental State Examination from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of global health status |
| Change in Barthel Index from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of independent functioning and mobility in activities of daily living |
| Change in Fugl-Meyer Assessment from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of motor recovery after stroke |
| Change in Montreal Cognitive Assessment from baseline to end of treatment and to follow-up | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) | Measurement of global cognitive ability |
Outcome results
None listed