Pregnancy
Conditions
Keywords
Thyroid dysfunction, obstetric complications
Brief summary
Obstetric complications are common and can be responsible for maternal and foetal morbidity and mortality. Thyroid dysfunction has been identified as a possible cause of obstetric complications. Many studies have been conducted to estimate the prevalence and define the nature of obstetric complications observed in patients with thyroid dysfunction. However, women with obstetric complications are not systematically screened for thyroid dysfunction and no published study has evaluated the prevalence of thyroid dysfunction in women with an obstetric complication. As no consensus has been reached concerning systematic screening for thyroid dysfunction in pregnant women, the identification of new high-risk populations could possibly result in a change of clinical practice.
Interventions
BIOLOGICALblood samples
for the determination of thyroid hormones (TSH, FT3, FT4 ) and antibodies against the thyroid (anti TPO antibodies and anti thyroglobulin)
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
women attending the emergency room and/or hospitalised or followed for: * Spontaneous and/or repeated miscarriage * Foetal death * Pre-eclampsia * Retroplacental haematoma * Post-partum haemorrhage * Premature delivery * who consent to participate in the study. * Assessment of these women will include blood samples for a laboratory work-up and anti-thyroid antibodies.
Exclusion criteria
* normal pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of thyroid dysfunction | Day 0 | Estimate the overall and individual prevalence of thyroid dysfunction (hypothyroidism, hyperthyroidism and thyroid autoimmunity) in patients with obstetrical accident |
Countries
France
Outcome results
None listed