Electrohaemodynamic Activity in Epileptic Children : Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis

Electrohaemodynamic Activity in Epileptic Children: Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02814331

Acronym

NIRS Epilepsie

Enrollment

Registered

2016-06-27

Start date

2011-10-14

Completion date

2015-04-24

Last updated

2018-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Keywords

Video-EEG, near-infrared spectroscopy (NIRS)

Brief summary

Evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis to spatial localization of epileptogenic foci

Detailed description

This study is designed to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.

Interventions

DEVICEmultimodal high-resolution EEG-NIRS

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Children between the ages of 6 and 18 years * with drug-refractory partial epilepsy, presenting interictal spikes on standard EEG recordings.

Exclusion criteria

* Children with a serious congenital malformation. * Refusal from one of the parents or the child. * Children with generalized epilepsy or diffuse interictal spikes. * Children with severely impaired general status and vital functions. * Children with dermatosis of the face or scalp. * Children under the age of 6 years or adults over the age of 18 years.

Design outcomes

Primary

Measure	Time frame	Description
multimodal high-resolution EEG-NIRS	Day 0	to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.

Secondary

Measure	Time frame	Description
Functional MRI	Day 0	to analyse the temporal dynamics of haemodynamic changes surrounding epileptic spikes.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026