Hepatic Steatosis, Pituitary Gland Failure
Conditions
Brief summary
The investigator put forward the hypothesis that liver fat mass in patients with pituitary gland failure is greater than that in a control population. Failure of the anterior pituitary and more particularly impaired production of growth hormone (GH) could be the principal mechanism responsible for increased liver fat mass in these patients.
Interventions
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who have provided consent * Patients over 18 years * Patients with pituitary disease (Pituitary adenoma, anterior pituitary failure, craniopharyngioma, empty sella syndrome, hypophysitis, infiltration of the stalk) requiring Magnetic Resonance Imaging (MRI) of the pituitary.
Exclusion criteria
* Persons without national health insurance * Pacemaker (Contra-Indication for MRI) * Alcohol consumption greater than 4 glasses a day * Any treatment able to increase liver fat content (glitazones, systemic corticoids, immunosuppressants) are forbidden * Presence of metallic implants (Contra-Indication for MRI) * Claustrophobia * Adult under guardianship * Pregnant or breast-feeding women * Patients with a liver disease other than non-alcoholic steatosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of liver fat mass by Magnetic Resonance Imaging (MRI) | Measured at Day 0 |
Countries
France
Outcome results
None listed