Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02814162

Enrollment

100

Registered

2016-06-27

Start date

2016-04-30

Completion date

2017-08-31

Last updated

2017-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subarachnoid Hemorrhage, Aneurysmal

Keywords

Subarachnoid Hemorrhage, Aneurysmal, Predictive, Adiponectin

Brief summary

The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.

Detailed description

Adiponectin (APN) is an abundant protein hormone derived from adipose tissue. It has been suggested to exert anti-inflammatory, antiatherogenic, and vascular protective. Subarachnoid hemorrhage (SAH) comprises about 5% of all strokes with high mortality and permanent disability rates. Although many patients survive from the initial hemorrhage or rebleeding, they suffered from long-term delayed neurological deficits (DNDs), including stroke, delayed cerebral ischemia, cognitive and neuropsychological abnormalities that seriously impact overall function and quality of life. Ruptured cerebral aneurysms are the most common cause of SAH. There is growing evidence supporting APN act as a predictive factor for SAH. The observational study will focus on the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage (aSAH).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* Age\>18yrs and age\<90yrs * It shows subarachnoid hemorrhage (SAH) based on computed tomography (CT) scan on admission * Aneurysmal subarachnoid hemorrhage confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA) * SAH grade is assessed by Hunt & Hess classification * Informed consented

Exclusion criteria

* Traumatic subarachnoid hemorrhage * Patients with cerebral herniation or highly possible to occur within 2 days from SAH * Length of hospital stay is expected to be less than 5 days * Duration from onset to admission is more than 48 hours * Disturbance of communication or poor compliance to blood collection, imaging examination and follow-up

Design outcomes

Primary

Measure	Time frame	Description
Incidence of cerebral vasospasm and delayed cerebral ischemia	30 days post SAH	Proved by clinical and radiologic evidence

Secondary

Measure	Time frame	Description
Death	30 days post SAH	—
National institutes of health stroke scale (NIHSS) score	On discharge or 14 days (whichever occurs first) and 30 days post SAH	Assessing by senior neurosurgeons
Modified Rankin scale (mRS)	30 days and 90days post SAH	By phone call following-up

Countries

China

Contacts

Primary ContactYan Qu, M.D Ph.D

yanqu0123@icloud.com86-18629074363

Backup ContactMin Li, M.D Ph.D

neursylm@163.com86-15319053136

Outcome results