Proteomics of Papillary Thyroid Carcinoma

Differences Protein Expression in Papillary Thyroid Carcinoma

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02814032

Enrollment

Registered

2016-06-27

Start date

2016-06-30

Completion date

2024-06-30

Last updated

2023-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Papillary Thyroid Carcinoma

Keywords

proteomic, cervical lymph node metastasis

Brief summary

Thyroid carcinoma is the common endocrine system malignant neoplasm. At present it has become the malignant neoplasm of fastest growing incidence rate. More than 85% thyroid carcinoma is papillary thyroid carcinoma. Cervical lymph node metastasis is common in papillary thyroid carcinoma patients. This study aim to reveal protein expression differences between papillary thyroid carcinoma with cervical lymph node metastasis and without cervical lymph node metastasis.

Detailed description

1. Object: Patients aged 18-65 years; newly diagnosed papillary thyroid carcinoma with cervical lymph node metastasis and without cervical lymph node metastasis and undergone thyroidectomy according to the China thyroid association guidelines for the Management of thyroid nodule and thyroid cancer. 2. Clinical information, examination data: Information is obtained from medical record abstraction. 3. Samples: Fresh frozen thyroid tissues from each sample group(normal histology, benign disease, papillary thyroid carcinoma with cervical lymph node metastasis, papillary thyroid carcinoma without cervical lymph node metastasis ).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Newly diagnosed papillary thyroid carcinoma. * Undergo thyroidectomy according to the China thyroid association guidelines forthe Management of thyroid nodule and thyroid cancer.

Exclusion criteria

* Current substance abuse/dependence. * Daily tobacco and alcohol use. * Whole neck irradiation or surgery. * Prior cancer diagnosis or chemotherapy treatment. * Active autoimmune disorder. * Uncontrolled allergic condition or asthma. * Chronic use of oral steroid medication. * Hormone therapy (estrogen, progestin compounds).

Design outcomes

Primary

Measure	Time frame
differences in protein expression	6 months

Countries

China

Contacts

Primary ContactShan Jin, PhD

jinshangood@163.com+86-15849338280

Backup ContactYun-tian Yang, PhD

yangyuntian@sina.com+86-15849338737

Outcome results