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The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders

The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02813954
Enrollment
184
Registered
2016-06-27
Start date
2015-08-31
Completion date
2016-04-30
Last updated
2022-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Distress Syndrome, Transient Tachypnea of Newborn

Brief summary

Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress. While fetal urine is the major content of AF since 20th gestational week, fetal lung liquid (FLL) also acts as a minor content. Secretion of FLL depends on chloride transport and postnatal clearance of FLL is provided by active reabsorption of sodium (Na) ions. Down-regulation of epithelial Na channels (ENaCs) and an increase of pulmonary compliance accompany to pulmonary adaptation developing at the first hours of life. Lower genomic expression of Na channels in airways is shown to be associated to respiratory distress syndrome (RDS) in preterm. Although pH and electrolyte value of AF is thought to be relevant to fetal and maternal conditions such as gestational age, antenatal steroids and preterm birth, there is no study about this topic in the literature.

Interventions

analyzing amniotic fluid by blood gas device

Sponsors

Kanuni Sultan Suleyman Training and Research Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
No minimum to 25 Hours
Healthy volunteers
Yes

Inclusion criteria

Accepted to participate with informed consent Normal healthy pregnancies

Exclusion criteria

Congenital abnormalities Chromosomal abnormalities Blood contaminated AF Declined to participate

Design outcomes

Primary

MeasureTime frame
The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders8 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026